ID G5BWI9_HETGA Unreviewed; 508 AA.
AC G5BWI9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Poliovirus receptor-related protein 4 {ECO:0000313|EMBL:EHB13650.1};
GN ORFNames=GW7_00510 {ECO:0000313|EMBL:EHB13650.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13650.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB13650.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR EMBL; JH172217; EHB13650.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BWI9; -.
DR STRING; 10181.G5BWI9; -.
DR eggNOG; ENOG502R9I0; Eukaryota.
DR InParanoid; G5BWI9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd07704; IgC1_2_Nectin-3-4_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR033320; IgC1_2_Nectin-3-4-like.
DR PANTHER; PTHR23277:SF11; NECTIN-4; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EHB13650.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..508
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474946"
FT TRANSMEM 343..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 398..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 55299 MW; 7B5FB6A7E9488607 CRC64;
MPLSLGAEMW GPEAWLLLLL LASFTGRCRA GELETSDLVT VVLGQDANLP CIYRGDPEEQ
VAQVAWARVD ANEAAGELAL LHSKYGLHVS SAYEGRVEQP PPPRDPLDGS VLLRNAVQAD
EGEYECRVST FPSGSFQARL RLRVLVPPLP SLNPGPPLEE GQGLTLAASC TAEGSPAPSV
TWDTQVKGTT SSRSFKHSRS AAITSEFHLV PSRSMNGQPL TCVVSHPGLL QDQRITHTLQ
VAFLAEASVR GLEDQKLWHV GREGAMLKCL SEGQPPPSYN WTRLDGPLPT GARVEGGTLG
FPPLTAEHSG IYVCHVSNEL SSRDSRVTVD VLDPEDPGKQ VDLVSASVVV VGVIAALLFC
LLVVVVVLMS RYHRRKAQQM TQKYEEELTL TRENSIRRLH SHHSDPRNQP EESVGLRAEG
HPESLKDNSS CSVMSEEPEG RSYSTLTTVR EIETQTELLS PGSGRVEEEE DLDEGIKQAM
NHFVQENGTL RAKPTGNGIY INGRGHLV
//
