ID G5BYE5_HETGA Unreviewed; 1751 AA.
AC G5BYE5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Plexin-D1 {ECO:0000313|EMBL:EHB14306.1};
GN ORFNames=GW7_08001 {ECO:0000313|EMBL:EHB14306.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14306.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14306.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; JH172444; EHB14306.1; -; Genomic_DNA.
DR STRING; 10181.G5BYE5; -.
DR eggNOG; KOG3610; Eukaryota.
DR InParanoid; G5BYE5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1083..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..358
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1751 AA; 193979 MW; 750395BE6D70F926 CRC64;
MTGRLRMPVP SSSCTVQPRS LSRLLVGATY TGFGSAFFPR NRSLEDHRFE NTPEVAIRSL
DAQGDPARLF TFDLNPSDDN VLKIKQGAKE RHRLRFVRAF LHPPGVQPYA YLAFTSEARA
GDKDGQARSL LARICLPRGD AKKLTESYIE LGLQCAGGAG RGDLYSRLVS VFPARERLFG
VFERPPAIPA PRTAPAPAAL CAFLFADVQA AIRSARAACF VEPAAGVVAV LDSVVQGTGP
ACDRKRNLQL QPEQLDCGAA HLQHPLTILQ PLKATPVFRA PGLTAVAVAS ANNYMAVFLG
TATGRLLKLS LNESMQVVSR RMVTVAYGEP VHPIMQFDPT DPSYLYLMTS HQMARVKVAA
CEAHATCGDC VGAADAYCGW CVLETRCTMQ QDCDNSSQPH FWTSASEGPS RCPAMAVLPA
EIDVHLEHPG MILQVSGSLP SLSGLEMACD YGNGIHTVAR VPGPADGHQI TYCNLLPRDH
FPAFPPQQDH VTVEMSLRVH GRAIVSANFT IYDCSRVAHV APSTACTSCL SARWPCFWCT
EQHICISNQS QCQASSNPKS PRDCPQTLPS PLAPAPTGGA QDILVPLANA ASFHGAVLQC
SFGLEDNFEA VWVNESAIRC SHVVLHTAQK SQMFLLSLQL QGQPPRFLDS PDPMTVVVYN
CAMGSPDCSQ CLGREDLGHL CMWSDGCRSR GPLPPQPGTC PAPEIHTIEP LSGPLDGGTL
LTIRGRDLGR RLSDVAHSVW IGSVACELLA NRYIVSEEIV CVTGPATAAF SDVVTVNMSK
EGTSRERFSY VLPQVHSLEP AVGPTAGGTR ITIHGSDLHV GSKLQVLVND TDPCTELVRS
DTSIACTMPA GALPAPVPVC VRFERRGCAH GNLSFTYMRN PVIMAISPRR SPVSGGRTIT
VAGERFHMVQ NVSMAVHRIG REPTLCKVLN ATLITCPSPG ALHNASAPVA FFINGRVYVD
EAPYEPLPDP EEMPRGGRFH LDYLPNPQFS TARRERWIRH HPGEPLTLVI HKEQDGLGLE
SHEYQVKIGQ VACDIQIVSD RVIHCSVNDS LDAAEGQLPI TVQVGNFNQT IATLQLGGSE
TTIVASIVIF SVLLLLSVVA LFFFCTKSRR AERYWQKTLL QMEEMESQIR EEIRKGFAEL
QTDMTDLTKE LSRSQGIPFL EYKHFVTRTF FPKCSSLYEE RYMLPLQSLG SKGGLPVQET
HPLLGEWNVP ENCRPSMEEG ISLFSSLLSN KHFLIIFVHA LEQQKDFAVR DRCSLASLLT
IALHGKLEYY TSIMKELLVD LIDASAAKNP KLMLRRTESV VEKMLTNWMS ICMYSCLRET
VGEPFFLLLC AIKQQINKGS IDAITGKARY TLNEEWLLRE NIEAKPRNLN VSFQGCGMDS
LSVRAMDTDT LTQVKEKILE AFCKNVPYSQ WPRAEDVDLE WFATSTQSYI LRDLDDTSVV
EDGRKKLNTL AHYKIPEGAS LAMSLTDKKD NTLGRVKDLD TEKYFHLVLP TDELAEPKKS
HRQSHRKKVL PEIYLTRLLS TKGTLQKFLD DLFKAILSIR EDKPPLAVKY FFDFLEEQAE
KRGISDPDTL HIWKTNSLPL RFWVNILKNP QFVFDIEKTD HIDACLTVIA QAFIDACSIS
DLQLGKVGFL GGTVEWGGSH RDSPTNKLLY AKEIPEYRKV VQRYYKQIQD MAPLSEQEMN
AHLAEESRKY QNEFNTNVAL AEVYKYAKRY RPQIVTALEA NPTARRTQLQ HKFEQVVALM
EDNIYECYSE A
//
