ID G5C029_HETGA Unreviewed; 238 AA.
AC G5C029;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Synaptosomal-associated protein 29 {ECO:0000256|ARBA:ARBA00041113};
DE AltName: Full=Soluble 29 kDa NSF attachment protein {ECO:0000256|ARBA:ARBA00042308};
DE AltName: Full=Vesicle-membrane fusion protein SNAP-29 {ECO:0000256|ARBA:ARBA00043032};
GN ORFNames=GW7_01811 {ECO:0000313|EMBL:EHB14890.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB14890.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB14890.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment
CC protein receptors, are essential proteins for fusion of cellular
CC membranes. SNAREs localized on opposing membranes assemble to form a
CC trans-SNARE complex, an extended, parallel four alpha-helical bundle
CC that drives membrane fusion. SNAP29 is a SNARE involved in autophagy
CC through the direct control of autophagosome membrane fusion with the
CC lysososome membrane. Also plays a role in ciliogenesis by regulating
CC membrane fusions. {ECO:0000256|ARBA:ARBA00037064}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00037808}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037808}. Cytoplasmic vesicle, autophagosome
CC membrane {ECO:0000256|ARBA:ARBA00037854}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037854}.
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DR EMBL; JH172626; EHB14890.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C029; -.
DR STRING; 10181.G5C029; -.
DR InParanoid; G5C029; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR CDD; cd15856; SNARE_SNAP29C; 1.
DR CDD; cd15887; SNARE_SNAP29N; 1.
DR Gene3D; 1.20.5.110; -; 2.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19305; SYNAPTOSOMAL ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR19305:SF9; SYNAPTOSOMAL-ASSOCIATED PROTEIN 29; 1.
DR SMART; SM00397; t_SNARE; 2.
DR SUPFAM; SSF58038; SNARE fusion complex; 2.
DR PROSITE; PS50192; T_SNARE; 1.
PE 4: Predicted;
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 176..238
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 207..234
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 26586 MW; F5652902850D375E CRC64;
MRRTKIHGQH RGKTPVIPPT GPPPTQTDSN TCGSRAEAHG RSTSRSLSLM YESEKVGVAS
SEELVRQRGV LERTEKMVDK MDQDLKTSQR HINSIKSVFG GFVNYFKSKP AETSAEQNGV
LAPQSNSRLK EAISTSKEQE EKYQANHPNL RKLDDVDSQT GSAVNTEAYS KNPHLQAYHQ
KIDSNLDELS LGLGRLKDIA LGMQTEIEEQ DDILDRLTTK VDKLDINIKS TEKKVQQL
//
