ID G5C0L4_HETGA Unreviewed; 345 AA.
AC G5C0L4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Zinc-binding alcohol dehydrogenase domain-containing protein 2 {ECO:0000313|EMBL:EHB15075.1};
GN ORFNames=GW7_03543 {ECO:0000313|EMBL:EHB15075.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB15075.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB15075.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR EMBL; JH172720; EHB15075.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C0L4; -.
DR STRING; 10181.G5C0L4; -.
DR eggNOG; KOG1196; Eukaryota.
DR InParanoid; G5C0L4; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08250; Mgc45594_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR43677:SF3; PROSTAGLANDIN REDUCTASE 3; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 12..335
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 345 AA; 36855 MW; 3C9EBBDDFA4C6FF2 CRC64;
MQKLVVTRLS PNFRDAVTLC RDCPVPLPGD RDLLVRNRFV GINASDINYS AGRYDPSVKP
PFDIGFEGIG EVVALGLSAS ARYTVGQAVA YMTPGSFAEY TVVPDNHATP VPSVKPEYLT
LLVSGTTAYL SLKELGELSE GKKVLVTAAA GGTGQFAVQL SKKAKCHVIG TCSSDEKSAF
LKSIGCDRPI NYKTEPVGTI LKHEYPEGID VVYESVGGAM FDLAVDALAT KGRLIVIGFI
SGYQSPTGLS PVKAGTLPVK LLKKSASICG FLLNHHLSKY QAAMEHLLKL CASGDLACEV
DLGDLSLEGR FTGLNSIFRA VDYMYMGKNT GKIVVELPHS VNSKL
//