ID G5C393_HETGA Unreviewed; 573 AA.
AC G5C393;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Arylsulfatase I {ECO:0000313|EMBL:EHB16004.1};
GN Name=ARSI {ECO:0000313|EMBL:JAN96445.1};
GN ORFNames=GW7_00117 {ECO:0000313|EMBL:EHB16004.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16004.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16004.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN96445.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAN96445.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; JH173150; EHB16004.1; -; Genomic_DNA.
DR EMBL; GEBF01007187; JAN96445.1; -; Transcribed_RNA.
DR RefSeq; XP_004854476.1; XM_004854419.1.
DR AlphaFoldDB; G5C393; -.
DR STRING; 10181.G5C393; -.
DR GeneID; 101723265; -.
DR KEGG; hgl:101723265; -.
DR CTD; 340075; -.
DR eggNOG; KOG3867; Eukaryota.
DR InParanoid; G5C393; -.
DR OMA; WDWMKPS; -.
DR OrthoDB; 2913702at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000007275; Expressed in zone of skin and 2 other cell types or tissues.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF68; ARYLSULFATASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..573
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007660917"
FT DOMAIN 48..359
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 509..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64675 MW; C22B5CF40DDA0411 CRC64;
MHALTGFSLV SLLSFGYLSW DWAKPSLVAD GPREDGEEQP SAAPPQPPHI IFILTDDQGY
HDVGYHGSDI ETPTLDRLAA EGVKLENYYI QPICTPSRSQ LLTGRYQIHT GLQHSIIRPR
QPNCLPLDQV TLPQKLQEAG YSTHMLGKWH LGFYRKECLP TRRGFDTFLG SLTGNVDYYT
YDNCDGPGVC GFDLHEGESV AWGLSGQYST MLYAQRASHI LASHSPQRPL FLYVAFQAVH
TPLQSPREYL YRYRTMSNVS RRKYAAMVTC MDEAVRNITW ALKRYGFYNN SIIIFSSDNG
GQTFSGGSNW PLRGRKGTYW EGGVRGLGFI HSPLLKRKRR TSHALVHITD WYPTLVGLAR
GTVSAADGLD GYDVWPAISE GRASPRTEIL HNIDPLYNHA RHGSLEGGFG IWNTAIQAAI
RVGEWKLLTG DPGYGDWIPP QTLAAFPGSW WNLERMASAR QAVWLFNISA DPYEREDLAG
QRPDVVRALL ARLADYNRTA IPVRYPAENP RAHPDFNGGA WGPWASDEED EEDDDEESRA
RSFSRGHHKK KCKICKLRSF FRKLNTRLMS HRI
//
