ID G5C5X1_HETGA Unreviewed; 548 AA.
AC G5C5X1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Polypyrimidine tract-binding protein 1 {ECO:0000256|ARBA:ARBA00019540};
DE Flags: Fragment;
GN ORFNames=GW7_08108 {ECO:0000313|EMBL:EHB16932.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB16932.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB16932.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH173462; EHB16932.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C5X1; -.
DR STRING; 10181.G5C5X1; -.
DR eggNOG; KOG1190; Eukaryota.
DR InParanoid; G5C5X1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12777; RRM1_PTBP1; 1.
DR CDD; cd12782; RRM2_PTBP1; 1.
DR CDD; cd12695; RRM3_PTBP1; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035000; PTBP1_RRM1.
DR InterPro; IPR035001; PTBP1_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF19; POLYPYRIMIDINE TRACT-BINDING PROTEIN 1; 1.
DR Pfam; PF13893; RRM_5; 3.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 47..131
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 173..249
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 352..426
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 469..546
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB16932.1"
SQ SEQUENCE 548 AA; 58725 MW; 2E39AC81BB069C56 CRC64;
QRGSDELFST CVTNGPFIMS SNSASTANGN DSKKFKGDSR SAGVPSRVIH IRKLPSDVTE
GEVISLGLPF GKVTNLLMLK GKNQAFIEMN TEEAANTMVN YYTSVTPVLR GQPIYIQFSN
HKELKTDSSP NQAVRAHAAL QAVNSVQSGN LALAASAAAV DAGMAMAGQS PVLRIIVENL
FYPVTLDVLH QIFSKFGTVL KIITFTKNSQ FQALLQYADP VSAQHAKLSL DGQNIYNACC
TLRIDFSKLT SLNVKYNNDK SRDYTRPDLP SGDSQPSLDQ TMAAAFGAPG IISASPYAGA
GFPPTFAIPQ AAGLSVPNVH GALAPLAIPS AAAAAAAAGR IGIPGLGGAG NSVLLVSNLN
PERVTPQSLF ILFGVYGDVQ RVKILFNKKE NALVQMADGS RAQLAMSHLD GHKLHGKPIR
ITLSKHQNVQ LPREGQEDQG LTKDYGNSPL HRFKKPGSKN FQNIFPPSAT LHLSNIPPSI
SISEEDLKSL FSSNGGVVKG FKFFQKDRKM ALIQMGSVEE AVQALIDLHN HDLGENHHLR
VSFSKSTI
//
