ID G5C8Q8_HETGA Unreviewed; 319 AA.
AC G5C8Q8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Dehydrogenase/reductase SDR family member 9 {ECO:0000313|EMBL:EHB17919.1};
GN Name=DHRS9 {ECO:0000313|EMBL:JAO01157.1};
GN ORFNames=GW7_06211 {ECO:0000313|EMBL:EHB17919.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB17919.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB17919.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAO01157.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAO01157.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
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DR EMBL; JH173922; EHB17919.1; -; Genomic_DNA.
DR EMBL; GEBF01002476; JAO01157.1; -; Transcribed_RNA.
DR RefSeq; XP_004857678.1; XM_004857621.1.
DR RefSeq; XP_004857679.1; XM_004857622.2.
DR AlphaFoldDB; G5C8Q8; -.
DR STRING; 10181.G5C8Q8; -.
DR Ensembl; ENSHGLT00100006947; ENSHGLP00100006855; ENSHGLG00100005141.
DR GeneID; 101716890; -.
DR KEGG; hgl:101716890; -.
DR CTD; 10170; -.
DR eggNOG; KOG1610; Eukaryota.
DR InParanoid; G5C8Q8; -.
DR OMA; VETEWIM; -.
DR OrthoDB; 5403248at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000007470; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:Ensembl.
DR GO; GO:0047044; F:androstan-3-alpha,17-beta-diol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0047023; F:androsterone dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:Ensembl.
DR GO; GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
DR GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
DR CDD; cd09805; type2_17beta_HSD-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43313:SF15; DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 9; 1.
DR PANTHER; PTHR43313; SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..319
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007660832"
SQ SEQUENCE 319 AA; 35168 MW; 6630B264847ADE2F CRC64;
MFLWVLALLI LCAFLWNCKG RLKIADINDK YIFITGCDTG FGNLAARTFD KKGFHVIAAC
LTESGSTALK AETSQRLRTV LLDVTDPENV KRTAQWVKNQ VGEKGLWGLI NNAGVLGVLA
PTDWLTVEDY REPIEVNLFG LISVTLNMLP LVKKARGRVI NVSSIGGRLA IGGGGYAPSK
YAVEGFNDSL RRDMKAFGVY VSCIEPGLFK TQLSDPIKTT EKKLAIWKHL SPDIKQQYGE
GYIEKSLDKL KSTASCVNVD LSLVVECMDH ALTSLFPKTR YAAGKDAKAF WIPLSHMPAV
LQDFLLLKQK VELANPKAV
//
