ID G5C9A8_HETGA Unreviewed; 953 AA.
AC G5C9A8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 3 {ECO:0000256|ARBA:ARBA00040040};
GN ORFNames=GW7_06486 {ECO:0000313|EMBL:EHB18119.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB18119.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB18119.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|ARBA:ARBA00004267}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004394}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; JH174047; EHB18119.1; -; Genomic_DNA.
DR AlphaFoldDB; G5C9A8; -.
DR STRING; 10181.G5C9A8; -.
DR InParanoid; G5C9A8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..91
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 213..300
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 723..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..740
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 107604 MW; 52B8183F3E9BD008 CRC64;
MASTRCRLAG YLEDLDCSDF KKFKMYLEDY PPQSGCTPLP RGQTERADHM DLATAMIDFN
GEEQAWTMAV WIFAAINRRD LHEKAKREQP QWDNPTVECR EDSIEEEWMG LLGFLSRISI
CKKKKDFSRT YRRHVRSKFH CIEDRNARLG ESVNLNKRYT RLQLVREHPS RQERERELLA
MGGSRLRDAP PGPLRLESLF DADPEDESLE PVHTVVVQGA AGIGKTILAR KIMLEWASGK
LFQDKFDYLF YIHCREVSLA TPRSLGELIA SCCPDAGPPV GRIVRKSSRV LFLMDGFDEL
QGAFDEHTGA LCTDWQKLQH LLERPRHVEV LGFSEARRKE YFFKYFSSEV QAQAAFSLIQ
ENEVLFAMCF IPLVCWIVCT GLKQRMDSGE SLAQTSKTTT AVYRPRHVEV LGFSEARRKE
YFFKYFSSEV QAQAAFSLIQ ENEVLFAMCF IPLVCWIVCT GLKQRMDSGE SLAQTSKTTT
AVYVSFLSCL LQARGAGHEH QHSAPLRGLC SLAADGIWNQ KVLFEESDLR SHGLWEGDVS
AFLRMSLFQK EVDCEKLYSF IHMTFQEFFA AMYYVLGEEE GAGPAGSCME LPSRDVAVLL
ENYGRFEKGY LIFVVRFLFG LVNQERASYL EKNLSCKMSQ QIRAELLRWI EAKARAKKLQ
AQPSQLELFY CLFEMQEEGF VRRAMGHFPK IEVSLTTRMD HVVSSFCIRN CPSVQSLSLG
FLHNSPEEEE EEEEEEGEEG TGPPANGAHR LVSCCLTTAC CEDLAAALSA SGSLTRLYVG
ENALGDVGVR ALCDRASWAE CRLQKLGLVN SGLTSSGCSA LALVLRTTKS LTHLYLRGNA
LGDTGLKLLC VGLLHPGCVL QMLELDNCSL TSHSCWDLST VLTSSRSLRK LSLSNNDLGD
LGVMMLCEVL RQGACVLRSL QLNEMYFNYA TKCALETLQE EQPGLDLVFE PSW
//
