ID   G5CU46_ROULA            Unreviewed;       410 AA.
AC   G5CU46;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=vWF {ECO:0000313|EMBL:AEQ16330.1};
OS   Rousettus lanosus (Long-haired rousette) (Stenonycteris lanosus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Rousettus.
OX   NCBI_TaxID=77222 {ECO:0000313|EMBL:AEQ16330.1};
RN   [1] {ECO:0000313|EMBL:AEQ16330.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21961908; DOI=10.1186/1471-2148-11-281;
RA   Almeida F.C., Giannini N.P., DeSalle R., Simmons N.B.;
RT   "Evolutionary relationships of the old world fruit bats (Chiroptera,
RT   Pteropodidae): another star phylogeny?";
RL   BMC Evol. Biol. 11:281-281(2011).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN398281; AEQ16330.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5CU46; -.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR22588:SF3; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00092; VWA; 2.
DR   Pfam; PF16164; VWA_N2; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          39..215
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          260..410
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ16330.1"
FT   NON_TER         410
FT                   /evidence="ECO:0000313|EMBL:AEQ16330.1"
SQ   SEQUENCE   410 AA;  45493 MW;  CBDD7D294870C7FB CRC64;
     EPGGLEVPPT EVPGSPTTPY VEDTPEPPLH DFYCSKLLDL VFLLDGSNKL SEAEFEVLKV
     FVVGMMERLH ISQKRIRVAV VEYHDGSHAY LELRDRKRPS ELRRVASQVK YAGSSVASTS
     EVLKYTLFQI FSKVDRPEAS RVVLLLTASQ EPPKLARNLV RYVQGLKKKK VTVVPVGIGP
     HANLKQIRLI EKQAPENKAF VLSGVDELEQ RRDEIISYLC DLAPAAPAPT QPPPVAQVTV
     GPELLGVLSQ GPRRTSMVLD VVFVLEGSDK IGEANFNRSK EFMEAVIQRM DVSQESIHVT
     VLQYSYMVTV ESTFLEAQSK GDVLQRVREI RFRGGNRTNT GLALQYLSEH SFSTSQGDRE
     QAPNLVYMVT GNPASDEIKR MPGDIQVVPI GVGPQADVQE LERIGWPNAP
//