ID G5CZ37_9EUTH Unreviewed; 206 AA.
AC G5CZ37;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:AEP18891.1};
OS Podogymnura truei (Mindanao gymnure).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Galericinae;
OC Podogymnura.
OX NCBI_TaxID=48905 {ECO:0000313|EMBL:AEP18891.1};
RN [1] {ECO:0000313|EMBL:AEP18891.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; JN415064; AEP18891.1; -; Genomic_DNA.
DR AlphaFoldDB; G5CZ37; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF16164; VWA_N2; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..206
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP18891.1"
FT NON_TER 206
FT /evidence="ECO:0000313|EMBL:AEP18891.1"
SQ SEQUENCE 206 AA; 23070 MW; 4CEDE86EAB37A60F CRC64;
GQQEGTQVGP TEGLPSPTTA YIESTPEPPL HAFQCSKLLD LVFLLDGSSK LSEAEFGVLK
AFVLDVMERL HISQRRVRVA VVQYQIGSHA YLKLRDRKRP SEMRRIVSEM PWAGVQMSSN
TEVLKYILYQ MFSRIDRPEA ARVALLLTAS KETPAMARHL SHYLQGLKTK GVAVIPVGLG
PHVNFRQIRF IEKNSPQNKA FVLSSV
//
