ID   G5E356_9PIPI            Unreviewed;       264 AA.
AC   G5E356;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Putative mucolipin-2 {ECO:0000313|EMBL:AEQ18524.1};
DE   Flags: Fragment;
OS   Hymenochirus curtipes (western dwarf clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Pipinae; Hymenochirus.
OX   NCBI_TaxID=8362 {ECO:0000313|EMBL:AEQ18524.1};
RN   [1] {ECO:0000313|EMBL:AEQ18524.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:AEQ18524.1};
RA   Chain F.J.J., Evans B.J., Dushoff J.;
RT   "The odds of duplicate gene persistence after polyploidization.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; JP287820; AEQ18524.1; -; mRNA.
DR   AlphaFoldDB; G5E356; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        58..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        112..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..41
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          128..236
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ18524.1"
FT   NON_TER         264
FT                   /evidence="ECO:0000313|EMBL:AEQ18524.1"
SQ   SEQUENCE   264 AA;  30409 MW;  D5FBA0DF745CA7A4 CRC64;
     LQTIRHHELP DCYDFMVTTF DKAHSGRKIS LDNDAGIQEC RDWHVSGSMQ KNTHYMMIFD
     AAVILVCLSS LTLCIRSVVR GIQLQREYVS FIHHRLAKSV CLADRMEFVN GWYIMIIVSD
     GLSVIGSILK MTLRASLPNV IRFSCCAAMI YLGYCFCGWI VLGPYHIKFR SLNMVSECLF
     SLINGDDTFT TFSIMQQKSY LVWLFSRIYL YSFISLFIYM VLSLFIALIT DTYDTIKNYQ
     IDGFPESELH MFVSECKDLP TSGR
//