ID G5EFJ7_CAEEL Unreviewed; 3354 AA.
AC G5EFJ7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 {ECO:0000313|EMBL:CAB16307.2};
GN Name=wdfy-3 {ECO:0000313|EMBL:CAB16307.2,
GN ECO:0000313|WormBase:C26H9A.2a};
GN ORFNames=C26H9A.2 {ECO:0000313|WormBase:C26H9A.2a}, CELE_C26H9A.2
GN {ECO:0000313|EMBL:CAB16307.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB16307.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB16307.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB16307.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CAB16307.2; -; Genomic_DNA.
DR RefSeq; NP_001255656.1; NM_001268727.1.
DR SMR; G5EFJ7; -.
DR EPD; G5EFJ7; -.
DR PeptideAtlas; G5EFJ7; -.
DR EnsemblMetazoa; C26H9A.2a.1; C26H9A.2a.1; WBGene00007752.
DR GeneID; 178220; -.
DR AGR; WB:WBGene00007752; -.
DR WormBase; C26H9A.2a; CE42572; WBGene00007752; wdfy-3.
DR HOGENOM; CLU_000175_5_0_1; -.
DR OrthoDB; 47483at2759; -.
DR PhylomeDB; G5EFJ7; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007752; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; G5EFJ7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF4; BLUE CHEESE; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:G5EFJ7,
KW ECO:0007829|PeptideAtlas:G5EFJ7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2416..2543
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2574..2867
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3004..3045
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3286..3346
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2336..2409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3172..3210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2336..2350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2370..2389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2390..2407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3177..3209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3354 AA; 374515 MW; C345D9EC82731F00 CRC64;
METRDERTLS LLHLRKTFSE YLKIPVSGSR SNDPSRLLPL FHKVMSMYTP QQLNAEFKEV
VHFATFLCSV LVKEVRQRAA STGTIEAAQS IAEFLRPGTE LKGYTILEAI RFLLSSEDEI
MIDAACKVSL PSTLVKTIYL FFDLPAAATT VTVTDLTENA TETEDEMLKN NEKLHDMIGQ
IMEGLCRFKC VSEELVRKDD LLLLFVGTTS QVAEANNCWR KLCARLLEVI ADKSITNAVI
KYVIVKKCVR IFVKNLSSAP SNSHSDAQKT AESIICLSCF LKNSAYLTDQ LLDEFYEADG
YTVIKDFLLK SETDNEIVRN ILLMAISLVN SGKFEITPQY TSGLVQLPAF QLPIPAGNGL
SVRNLNAFAL LYHVFLESTS ESTSCTVIDI LHSIYTCDPA NYFILDKEYP LSIFIDQLER
KPHAVRVKLL ELIEFAVFQL SHIPCRELIS LCVLLKTEIS AGKTAMCTII VQMCFKLITV
DAIIKDAFRE VGLLDALCFI IRRMFEMYEK NIQNASFTVT STSSRSQDQL KLSLLTTDLL
TIIIKNNTEN GKLFTECFGA KLLIEIVCEV NEEWRSSLLQ LVKQLLIVAP TDQYIMHLVN
TLQDRIPIEN LEVMFSLLKA LLGVVRESHK VRIQFRKSGG FLALSALLLG LEKRFTDLHP
AGDGRIPREQ CQMLEFVHII FKVFTLSMRF EPSNAKYFST EITWDSITSL LRLTSIFNES
TVISIEETEW KSLTHTDLAS EIAACHEVFR LDDNIEAGNV PKGMPFNIYF GCYVCRLIFN
MALDNYEKMT SDIRWNDDGA SLEESIVSWT SSLLVHPGAI ISMLCLLPSI SASSMKWTIA
AQYYVSLLLK AILKSERNQQ IMCQVDMPKH LLRIAEKLFL TENHILLQPF YYLLERLSYQ
SLTPNQLRSF LRLDSPLCCR SLDDDEDDDD DSKIEIADNE GGPVPLQRVK ALVSMMTPRD
QYIGTAPSFV EFDMSVEGFA ALYLPSLAPM FSTTKAERIF PPLNGFSFCT WIYLDALSDK
KADAHPIRLL TVTRAVAPPN SDPPSKKPSQ TAHLACFQCQ FSAFDRSLLI STEESDQPGA
DLEKTANFQT DKLIRITLAD QVRCGEWFHL AVVFNRSVLK SSQVSLYLNG RHISTQKLMY
VAQNAGGAAT QLAQTYSVNA VVGTLPALRR PSRLRFRLAS IFLAEEPMTA ETVRAVVQLQ
PHYIGNYQTA STAPLFHEEK IVFSLSAAAT QELTLAKIRT MYGKMDAEIL SQHLGISPND
HSTPLRVLCN TISHAPGAGR TFGGVIVGYL GMRTFTPRPV PSLLDSIGGF ASVYGLIAMA
VDSEGLYASL KSLVSAIRSQ PRLLATWNNN RSYQILAVLL EDKAKMLNSH IMHMVFNVTG
TADTSREHAP TISNPSAFED LLCDLKVWKG APSELHKMLL EHFYELITDH QLNNLQVVRK
SSLLSRILLI IHDEPTMIKN TDEIIFNLIS AIMQPQCDSR SILKIGQSIA ATLPTSESEC
YEDSHLPFHI SEIQKLFIES SDPPPEALHQ VYIRNRLLNI IANFLANSNT QVQQQMCDQL
VRTLGFDWLF ALMSPGVHSG TIYLALRILL LILNQPSLLA RFKEGSANGG WLSEADSVVR
NRAAVVLGFS VSAHGGAVGS KIDINPELSN CGGFAALEHL MAAHADKPYP YYAMLSLLVG
QPISALRFCD QFNMELVWTH VFGLNSTSSV FEAINSANFC FDAIIPLFAM IRTSIYHQSS
IHQPWTVTNP STVVQMITFM YQNSPAFFNI AHTDEFILAL FSTLIEDTNA MGVKSEVANR
RSQDGGGSPD AEYFQAFLAQ PNVRIVMDLL KKICCDNLQV NTSKNDTIID AILDNISESG
NTRKTQIACL TSLLHSVLEH TVGTDLLSSS ALPPNTQAQN IVQIVANISL LSSRAVDAFW
NGLVFGSESM RMLSTLYHLQ VIASKKVNKA VNAEPITGCI MRMTLFILSR PIDSVPVQLS
VLDALSTLVS KRYLFLSSNE AWFFASLTHL IFMLSVTPDV LFQDNSSSSD LDRTSAQVAM
CACRVWSDVI CAKQALIEET FKKQSVTDIN AARALLSHSA GVYWQQFVDS QLRAIQTGGS
SAQGSAVTAK DIIQQQISSK FNRVASGITR FAAKRSMSTT TALPSSGSVA AWKSTSTDKQ
VIFMWLRVHV SLIKELVRAQ STRYTEWHAH VRKWCLHDWH QWEAELTRER GIWGPERASK
LEKFKLDLTE GPTTRMRRKL IPNRNFYHIY PFRPHLEAPS AKAQRAKVAI SFDSKPYYET
CLRHRRRTLD TRIIDSSNVS TASPEDGSGS SNLLGYSFTD LSQINSSLIR RLSTTAPATS
NVSGTSLELN EEECETSERK EDDESISSIS EKTDSNGVQS SGPSTSSNTT KEAKKEEKKE
EKKAGPDNQT LLRLLEQGEQ LHSMFRCARI QGLETAEGLL LFGRDHFYVV DGFTLLKTKE
IRDLDFLSQE MHDPIVPYPA TGATQPPKSS RLCSKFSYNM IREVHKRRYL LQPIALEVFS
SDGRNYLLAF PKKIRDRVFD KLTSMAINLS SGGSDSLGGQ KANVAIETTG RGASLLSSLI
GQQSVTQRWL SGNISNFQYL MHLNTLAGRC YNDLSQYPIF PWVLADYTSS QLDFNNISTF
RDFSKPMGAQ SPDRLEQFLK RFREWDDPSG ETPPYMYGTH YSSAMIVVSY LVRLEPFTQQ
FLSLQGGHFD LADRMFHSVG DAWTSASRNN MADVKELIPE FFTLPEMFTN TNHFDLGVKQ
NGIHVNDVLL PAWCHGDPRE FIRLHRQALE SDYVSSHLHE WIDLIFGYKQ NGEEAVKNSN
LFHHLFYEGS VDFERIDDPL TRNATIGFVN NFGQIPTQLF KKPHPQKKVN ILEGFSNTPG
VTTSRLFYHA IHNMSAPQTP FKELRSAIGS IHQNDKIGVV ALEQNKVFIG TNRYITWGLP
DRSVRMGQID NDKSVCVHEM CEVDEMTCAA AGDETTLFCG NTSGCITVWK VNNKPLSMKK
LSVLNGHSDA ITCLVSCQSH AVLVSASRDL TVLVWHLSEM FLIRQLPKHP HAVLAVAVND
ATGDIATACS TLLHVWTLNG ELLAVLNTCD VAPAIDPQQM IISLAFSTMN EWDNDNVIMC
GTSDGIVKIY SCVVFENDGS VSEHPALENP NSNSNENHDR SAAIAARLEK QRKRLKNSST
TATSSSVSGS GSASLTSPGP ASPSAGGSRA TNIDVGGAQF VRVLVQRTAL TMHTAFNRPD
NVHPAPITAI APSRDHRSLY VGDGIGRVWC WQSAEGGGRA DHWVQDVTRQ RCDDCEHKFT
LADRKHHCRN CGQIFCSTCS RFESHITRMN ISRPVRVCRK CFQRLQQSSN LHNL
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