ID G5QP33_SALRU Unreviewed; 321 AA.
AC G5QP33;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcriptional regulator LsrR {ECO:0000256|ARBA:ARBA00015912};
GN ORFNames=LTSERUB_4748 {ECO:0000313|EMBL:EHC82480.1};
OS Salmonella enterica subsp. enterica serovar Rubislaw str. A4-653.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=913081 {ECO:0000313|EMBL:EHC82480.1, ECO:0000313|Proteomes:UP000004903};
RN [1] {ECO:0000313|EMBL:EHC82480.1, ECO:0000313|Proteomes:UP000004903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4-653 {ECO:0000313|EMBL:EHC82480.1,
RC ECO:0000313|Proteomes:UP000004903};
RX PubMed=21859443; DOI=10.1186/1471-2164-12-425;
RA den Bakker H.C., Moreno Switt A.I., Govoni G., Cummings C.A., Ranieri M.L.,
RA Degoricija L., Hoelzer K., Rodriguez-Rivera L.D., Brown S., Bolchacova E.,
RA Furtado M.R., Wiedmann M.;
RT "Genome sequencing reveals diversification of virulence factor content and
RT possible host adaptation in distinct subpopulations of Salmonella
RT enterica.";
RL BMC Genomics 12:425-425(2011).
CC -!- FUNCTION: In the absence of autoinducer 2 (AI-2), represses
CC transcription of the lsrACDBFGE operon and its own transcription. In
CC the presence of AI-2, LsrR is inactivated by binding phospho-AI-2,
CC leading to the transcription of the lsr genes.
CC {ECO:0000256|ARBA:ARBA00025426}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00010466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHC82480.1}.
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DR EMBL; AFCT01001739; EHC82480.1; -; Genomic_DNA.
DR AlphaFoldDB; G5QP33; -.
DR PATRIC; fig|913081.3.peg.3671; -.
DR Proteomes; UP000004903; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR007324; Sugar-bd_dom_put.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR34294:SF12; TRANSCRIPTIONAL REGULATOR LSRR; 1.
DR PANTHER; PTHR34294; TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF04198; Sugar-bind; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 68..316
FT /note="Sugar-binding"
FT /evidence="ECO:0000259|Pfam:PF04198"
SQ SEQUENCE 321 AA; 34682 MW; 9D2783F3836FC20D CRC64;
MTMSDNTLVS DYGMCEEEQV ARIAWFYYHD GLTQSEISER LGLTRLKVSR LLEKGHQSGI
IRVQINSRFE GCLEYENALR NHFALQNIRV LPALPDADIG LRLGIGAAHM LMESLRPQQL
LAVGFGEATM TTLKRLSGFI SAQQIRLVTL SGGVGPYMTG IGQLDAACSV SIMPAPLRAS
SQEIACTLRN ENSVRDVMLT AQAADAAIVG IGAINQKDQA SILKSGYITQ GEQLMIGRKG
AVGDILGYFF DAHGEIIPDI KIHNELIGLK LNSLSTIPTV IGVAGGEQKA EAIIAAMRGN
YINALVTDQK TAGKIIQLIE K
//
