ID G5SG00_SALET Unreviewed; 571 AA.
AC G5SG00;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN ORFNames=LTSEWAN_4431 {ECO:0000313|EMBL:EHD00432.1};
OS Salmonella enterica subsp. enterica serovar Wandsworth str. A4-580.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=913086 {ECO:0000313|EMBL:EHD00432.1, ECO:0000313|Proteomes:UP000003536};
RN [1] {ECO:0000313|EMBL:EHD00432.1, ECO:0000313|Proteomes:UP000003536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4-580 {ECO:0000313|EMBL:EHD00432.1,
RC ECO:0000313|Proteomes:UP000003536};
RX PubMed=21859443; DOI=10.1186/1471-2164-12-425;
RA den Bakker H.C., Moreno Switt A.I., Govoni G., Cummings C.A., Ranieri M.L.,
RA Degoricija L., Hoelzer K., Rodriguez-Rivera L.D., Brown S., Bolchacova E.,
RA Furtado M.R., Wiedmann M.;
RT "Genome sequencing reveals diversification of virulence factor content and
RT possible host adaptation in distinct subpopulations of Salmonella
RT enterica.";
RL BMC Genomics 12:425-425(2011).
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHD00432.1}.
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DR EMBL; AFCX01001446; EHD00432.1; -; Genomic_DNA.
DR AlphaFoldDB; G5SG00; -.
DR PATRIC; fig|913086.3.peg.3408; -.
DR Proteomes; UP000003536; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 2.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR049034; T3S_SPI-1_N0.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 2.
DR Pfam; PF21304; T3S_SPI-1_N0; 2.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 29..69
FT /note="SPI-1 type 3 secretion system secretin N0"
FT /evidence="ECO:0000259|Pfam:PF21304"
FT DOMAIN 71..112
FT /note="SPI-1 type 3 secretion system secretin N0"
FT /evidence="ECO:0000259|Pfam:PF21304"
FT DOMAIN 119..178
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 193..311
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 367..525
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 571 AA; 62555 MW; 6291CBE5B9AC4117 CRC64;
MARVLACAAL VLVTPGYSGE KIPVTGSGFV AKDDSLRTFF DAMALQLKEP VIVSKMAARK
TARKKITGNG AAARKKITGN FEFHDPNALL EKLSLQLGLI WYFDGQAIYI YDASEMRNAV
VSLRNVSLNE FNNFLKRSGL YNKNYPLRGD NRKGTFYVSG PPVYVDMVVN AATMMDKQND
GIELGRQKIG VMRLNNTFVG DRTYNLRDQK MVIPGIATAI ERLLQGEEQP LGNIVSSEPP
AMPAFSANGE KGKAANYAGG MSLQEALKQN AAAGNIKIVA YPDTNSLLVK GTAEQVHFIE
MLVKALDVAK RHVELSLWIV DLNKSDLERL GTSWSGSITI GDKLGVSLNQ SSISTLDGSR
FIAAVNALEE KKQATVVSRP VLLTQENVPA IFDNNRTFYT KLIGERNVAL EHVTYGTMIR
VLPRFSADGQ IEMSLDIEDG NDKTPQSDTT TSVDALPEVG RTLISTIARV PHGKSLLVGG
YTRDANTDTV QSIPFLGKLP LIGSLFRYSS KNKSNVVRVF MIEPKEIVDP LTPDASESVN
NILKQSGAWS GDDKLQKWVR VYLDRGQEAI K
//
