ID G5ZWA5_9PROT Unreviewed; 959 AA.
AC G5ZWA5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=FAD/FMN-dependent dehydrogenase {ECO:0000313|EMBL:EHI49683.1};
GN ORFNames=HIMB100_00002960 {ECO:0000313|EMBL:EHI49683.1};
OS SAR116 cluster alpha proteobacterium HIMB100.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster.
OX NCBI_TaxID=909943 {ECO:0000313|EMBL:EHI49683.1, ECO:0000313|Proteomes:UP000004261};
RN [1] {ECO:0000313|EMBL:EHI49683.1, ECO:0000313|Proteomes:UP000004261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain HIMB100 {ECO:0000313|Proteomes:UP000004261};
RX PubMed=22675578; DOI=10.4056/sigs.1854551;
RA Grote J., Bayindirli C., Bergauer K., Carpintero de Moraes P., Chen H.,
RA D'Ambrosio L., Edwards B., Fernandez-Gomez B., Hamisi M., Logares R.,
RA Nguyen D., Rii Y.M., Saeck E., Schutte C., Widner B., Church M.J.,
RA Steward G.F., Karl D.M., Delong E.F., Eppley J.M., Schuster S.C.,
RA Kyrpides N.C., Rappe M.S.;
RT "Draft genome sequence of strain HIMB100, a cultured representative of the
RT SAR116 clade of marine Alphaproteobacteria.";
RL Stand. Genomic Sci. 5:269-278(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI49683.1}.
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DR EMBL; AFXB01000002; EHI49683.1; -; Genomic_DNA.
DR AlphaFoldDB; G5ZWA5; -.
DR STRING; 909943.HIMB100_00002960; -.
DR PATRIC; fig|909943.3.peg.307; -.
DR eggNOG; COG0247; Bacteria.
DR eggNOG; COG0277; Bacteria.
DR Proteomes; UP000004261; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000004261}.
FT DOMAIN 17..250
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 959 AA; 103717 MW; 6384D4AE0C78FE05 CRC64;
MSDRFSRGRY ATDASIYQML PHGVVVPETI DDVRVALAFA RDHGLSVLPR GGGTSQCGQT
VNHALVIDNT KHLKRLLSLD VENRRCVVEP GIVLDDLNRQ LKPHGLWFPV DVSTSSRATI
GGMTGNNSCG GRSIRYGIMR DNVTAIDAIM ADGSDSRFAA LDGDGLSGML ADLWPQLEAL
GRDNQEEILT RFPQILRRVG GYNIDALIPD AMALRPGGQA GDGLNLAHLL VGSEGTLAYS
TAIELKLSPL PAKKIMGICH FPTFYKAMDA AQHLVTLDPV AVELIDDTML ELARSIPIFK
PIVEEAVRGA PAALLVVEFA EEDEAENLRR LKRLHEMMSD LGFGWDKAAD WTGGVIDAID
PGLQGRVAEM RKSGLNIMMS MKQSAKPVSF VEDCAVELKH LADYTAGLTE IFEKHGTRGT
WYAHASVGCL HVRPVLDMKM GADVEKMRSI AEEAFALVQH YGGSHSGEHG DGIVRSEFNE
VMFGPKMAAL FRQVKAMFDP NGLFNPGKII DAPDMDSRDL FRFAPGYSVD EFPTQLDWSA
WPGAAGGLQG AVEMCNNNGA CRKLEGGVMC PSFRATGDEK DSTRGRANTL RLALSGQLGP
EAMASDEMAE TMKLCVSCKG CKRECPTGVD MARMKIEVTA LRAADKGLSL HDRLIAYLPA
YAPLAARCSG LVNLLQSARR HIPVLSSVLE KLTGFTARRD LPKWAPHPFR DAEADSAPEG
AKPVILFADT FNRYFEPENL RAALRVLNAA GYQVFIPASD NSIPLCCGRT YLSAGLVDKA
RQRAEHLVNT YLPFAEQGIP VVGLEPSCTL ALRDEVPALL ASAAARTVAE HVLTFEELLA
RDKPELKLSK SGGQALLHGH CHQKAFDVVK PVETVLSELA GFEVEQIETS CCGMAGAFGY
GADTFDISMK MGASKLFPKV EQASADTVVV ADGTSCRCQI ADGTGRDARH VAAILADRL
//
