ID   G5ZY22_9PROT            Unreviewed;       513 AA.
AC   G5ZY22;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Choline-sulfatase {ECO:0000313|EMBL:EHI49008.1};
GN   ORFNames=HIMB100_00009240 {ECO:0000313|EMBL:EHI49008.1};
OS   SAR116 cluster alpha proteobacterium HIMB100.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster.
OX   NCBI_TaxID=909943 {ECO:0000313|EMBL:EHI49008.1, ECO:0000313|Proteomes:UP000004261};
RN   [1] {ECO:0000313|EMBL:EHI49008.1, ECO:0000313|Proteomes:UP000004261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain HIMB100 {ECO:0000313|Proteomes:UP000004261};
RX   PubMed=22675578; DOI=10.4056/sigs.1854551;
RA   Grote J., Bayindirli C., Bergauer K., Carpintero de Moraes P., Chen H.,
RA   D'Ambrosio L., Edwards B., Fernandez-Gomez B., Hamisi M., Logares R.,
RA   Nguyen D., Rii Y.M., Saeck E., Schutte C., Widner B., Church M.J.,
RA   Steward G.F., Karl D.M., Delong E.F., Eppley J.M., Schuster S.C.,
RA   Kyrpides N.C., Rappe M.S.;
RT   "Draft genome sequence of strain HIMB100, a cultured representative of the
RT   SAR116 clade of marine Alphaproteobacteria.";
RL   Stand. Genomic Sci. 5:269-278(2011).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHI49008.1}.
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DR   EMBL; AFXB01000007; EHI49008.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5ZY22; -.
DR   STRING; 909943.HIMB100_00009240; -.
DR   PATRIC; fig|909943.3.peg.937; -.
DR   eggNOG; COG3119; Bacteria.
DR   OrthoDB; 9795675at2; -.
DR   Proteomes; UP000004261; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16032; choline-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017785; Choline-sulfatase.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   NCBIfam; TIGR03417; chol_sulfatase; 1.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004261}.
FT   DOMAIN          5..353
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   513 AA;  58039 MW;  A2BD5F12CED67584 CRC64;
     MSRKPNILLF MVDQLTAFVL SAYGGTVCKT PNLDKLARNG TVFEQAFCTY PLCAPSRCSL
     MSGRLPSRIS AFDNGAEFPA SVPTFTHYLR LAGYYTCISG KMHFVGPDQF HGFEERLTPE
     IYPADMSWTP DGDFRDITGG ENEVRSFGVS TLDTVRDAAP VAHSMQIEYD EDVVHQARRE
     IFALKRRQET RPFFMTVSLT QPHDPYVTKQ KYWDLYQDVE IDDPRAAFIP LKDRDPHSQS
     LYYHYSQHKL ALTDQDYRRA RRGYYGMISH IDELFGHVIE ALMQAGFGDN TVVVFTSDHG
     DMIGERGMWF KKTLFNPAIQ VPLIVSLPDQ KEQRVTHPVS LLDLFPTFLG LAGLDNDEIP
     TQLDGRSLLP ALMGGTVIGP VFAEHIDGGT AAPRVSVRDK DKKIVLSEAY PPQFYDLSVD
     PLELNNLAGQ GHPDEQRLTA IATSHWNLAE LKQRVLSSQS ERRVVDRALA TGREERWDFE
     TTGRLSEGNY VRRGDQFPDI ERQGYIAINS RNK
//