ID   G7CJE5_MYCT3            Unreviewed;       341 AA.
AC   G7CJE5;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Pyruvate dehydrogenase E1 component subunit beta {ECO:0000313|EMBL:EHI12743.1};
GN   ORFNames=KEK_17628 {ECO:0000313|EMBL:EHI12743.1};
OS   Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP
OS   105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1078020 {ECO:0000313|EMBL:EHI12743.1, ECO:0000313|Proteomes:UP000004915};
RN   [1] {ECO:0000313|EMBL:EHI12743.1, ECO:0000313|Proteomes:UP000004915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 /
RC   316 {ECO:0000313|Proteomes:UP000004915};
RG   Tuberculosis Structural Genomics Consortium;
RA   Ioerger T.R.;
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHI12743.1}.
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DR   EMBL; AGVE01000046; EHI12743.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7CJE5; -.
DR   PATRIC; fig|1078020.3.peg.3477; -.
DR   eggNOG; COG0022; Bacteria.
DR   Proteomes; UP000004915; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Pyruvate {ECO:0000313|EMBL:EHI12743.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004915}.
FT   DOMAIN          19..194
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   341 AA;  37137 MW;  D1A84FDD7D32856F CRC64;
     MTQLIERPLV TARPPVPELT LAQAVNRALH DAMAADQRVL VFGQDVARLG GVFRVTDGLS
     AAFGEERCFD TPLAESAIIG IAIGLAIRGF VPVPEIQFDG FSYPAFDQIV SHLAKYRMRT
     RGDVEMRVTV RIPSFGGIGA VEHHSESTET YWLHTAGLKV VAPGTPADAY WLLRHAITCP
     DPVIYLEPKR RYWARGPVDT TTPAGPLGRA AVARSGTDVT VITYGSLVTT ALSAAELAAD
     THGWSLEVVD LRSLNPLDFD TIAESVRRTG RAVVLHEGPR TLGFGAELAA RITEELFYDL
     EAPVLRATGF DTPYPPARLE KLWLPGPDRL LDCVERSLGY P
//