ID G7DVB6_MIXOS Unreviewed; 1552 AA.
AC G7DVB6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Probable metalloreductase AIM14 {ECO:0000256|ARBA:ARBA00039704};
GN Name=Mo01178 {ECO:0000313|EMBL:GAA94526.1};
GN ORFNames=E5Q_01178 {ECO:0000313|EMBL:GAA94526.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA94526.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- FUNCTION: Probable cell surface metalloreductase. May be involved in
CC iron or copper homeostasis. {ECO:0000256|ARBA:ARBA00037386}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ferric reductase (FRE) family. AIM14
CC subfamily. {ECO:0000256|ARBA:ARBA00038065}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA94526.1}.
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DR EMBL; BABT02000037; GAA94526.1; -; Genomic_DNA.
DR STRING; 764103.G7DVB6; -.
DR eggNOG; KOG0039; Eukaryota.
DR HOGENOM; CLU_003645_0_0_1; -.
DR InParanoid; G7DVB6; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972:SF69; METALLOREDUCTASE AIM14-RELATED; 1.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SFLD; SFLDS00052; Ferric_Reductase_Domain; 1.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..434
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 778..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 172388 MW; F3A52C72A4180C21 CRC64;
MDEERENVPD RDIMNEYGLG RLASYDRPEL LEEDVKPDYL TRNKSERLRL QGLLLSKMSR
PPSRLDVDER VLDAPVTRGE AFALWMVNEG RRRIFFGVFL IVQTLVFVLG FVNYAYSDNF
DNARATFHIT YPIARAAALT LHFDLALILL PVCRNMISFL RNTPLGAVIP FDSNITFHKA
VAWSMVFFTA VHVTAHMVNF AQLGIASGTN VVGFLGANFA TGPGITGWIM TLALAVMVWT
AIEKNRRANF ERFWYAHHLG LVFFLMWSIH GMFCMIQPDR PPYCSASSIG IFWRYWLVGG
TIYSYERILR ELRSRHKTYI TKVIQHPSNV VEIQFQREGA VSRPGQYIFL NCPAISLWQW
HPFTLTSAPE HGYLSVHIRM VGDFTRALGE ALGCDLEGDK GGAAKAGSQE IQVTNKQVLP
RIMIDGPFGS SSEDYRKFDT VVLVGAGIGI TPFASILSSI WYQKNEARRR GKKTRLTKVY
FFWICRDTTT LSWFQNLLSA IEDQDDEGYV EIHTYVTQRL KEAELNNLMI ADVGSERDSI
TGLKAPTHFG RPNWSAIFQS LQHRHPSTEV GVFFCGPKPL GSALHLLGNF ACSDTIMDKL
RKRSWLRPVK SKNALQGATD AVSTASQISV EVSHQQTSAR ERSWPSLSIR ATLDSRFMSS
RASSIPQATS PSYMGSDAHS LSTLTSSCRP EPRYLVAGEI PRPTLVIEDV QLFDVCNASP
AYDDAREDQD SVASPASVLG RQSTVCLRRM GIDTDAESGA DPDLKRFSFP LPASTSVGSR
ASLVKEPAGS RVLTPASSPA VASPSSRSPQ SRSPTGYGPS SALARRPSTS AALSLMPKHP
TTEYLADQLN SKQEYASSES AMTEPRRPSS PAPLGRADQV LIPARRDSVD SAEEALRDLN
LTSTDETVSR PVAFSYGPTR PVRTKQSPDL STQWRRVDEL TAARSSDPSK SPQKPSGREH
TLRSPASADN IVQIHRDPAL ASSGNRLSKS GVSINSTSTE SLSMWPRTDS FPATLHREAM
HDRSDLPANM PEWSRLQADE PTSYPNNKIV RDLDFAMRKL LSEAVFKDFL EDPLARWRFR
EYLKTTRGDP PYLLDCWWDA ELFARQFRAL RQGAHDFGQL YLQPTVAISD KVGVSSDKMS
DASLVLDSIA TASNPVARIQ DDMLRTMFKT DFQSFVKTRL VEQARVKLGS FTLRDKEKGQ
GLGDCFVITN PRQRDHPIIG ASDAFVELTG YSRQAICSRN CRFLQGPSTS REAVARIRVA
LNTGQACTEL LLNYRQNGQP FFNLLCIFPL RDTDGSVSYY CGGQINVSGP LKSSKSLRFL
VGIEDEEPNG AGSEVEPSPT MSQYLTHKRS NLESPAQCNP LFPSAAGYQP SSAELSRHTS
ARSAIVLDSL ANGKEPQQTP GPGAEQQFRV KEAKGIDEAS REFESVYSKA IFLEPHRCKI
LFATEPFLEY LGLPTSTAKE RFNSAVLRQD LTDLLHSPKP EGTKRLRDQV RAAIAEGQAF
SVLTDIKISS TSLSHIIPRK KTLARQRGML HATPIKDTSG SIFAFVALFG TD
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