ID G7G1Z6_9GAMM Unreviewed; 415 AA.
AC G7G1Z6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:GAA79419.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:GAA79419.1};
GN Name=metB {ECO:0000313|EMBL:GAA79419.1};
GN ORFNames=P20495_1920 {ECO:0000313|EMBL:GAA79419.1};
OS Pseudoalteromonas sp. BSi20495.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=386429 {ECO:0000313|EMBL:GAA79419.1, ECO:0000313|Proteomes:UP000003050};
RN [1] {ECO:0000313|Proteomes:UP000003050}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSi20495 {ECO:0000313|Proteomes:UP000003050};
RX PubMed=22275105; DOI=10.1128/JB.06427-11;
RA Bian F., Xie B.B., Qin Q.L., Shu Y.L., Zhang X.Y., Yu Y., Chen B.,
RA Chen X.L., Zhou B.C., Zhang Y.Z.;
RT "Genome sequences of six Pseudoalteromonas strains isolated from Arctic sea
RT ice.";
RL J. Bacteriol. 194:908-909(2012).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA79419.1}.
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DR EMBL; BADY01000064; GAA79419.1; -; Genomic_DNA.
DR RefSeq; WP_008135890.1; NZ_BADY01000064.1.
DR AlphaFoldDB; G7G1Z6; -.
DR Proteomes; UP000003050; Unassembled WGS sequence.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR011821; O_succ_thio_ly.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR02080; O_succ_thio_ly; 1.
DR PANTHER; PTHR11808:SF75; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Transferase {ECO:0000313|EMBL:GAA79419.1}.
FT MOD_RES 198
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 415 AA; 44872 MW; 6EF28768B3D2B265 CRC64;
MSEKNKATIA VRSGVEADKH HGAVVAPIYL STTYSFADFD TKRQYDYGRS GNPNRDILAE
TLAELEGGVR GIITATGMAA VHLATQLLNY DDTLVIPHDC YGGSYRLFTS LQKRGLLKLE
VLDLTKPESL QKILVIKPKL IWIETPSNPV LRLTDIKAVT DIAKQCGALV AADNTFLSPA
LQNPIKFGVD IVVHSTTKYI NGHSDVVGGA VIAATQEIGD ELAWWANNIG ITGAPFDSYL
TLRGLRTLNV RLRQHQENAL AIAKYLEESE FVSQVYYPGL ESHPQHELAK AQQLGFGGMV
SFDIKGDIND AAAFLTSLHN FSLAESLGGV ESLICHPATM THAGMDATAR LEAGVGDTLI
RVSVGIEDIE DLLADLERVF TLVKPGRKNN TNRLTKGAGT SSGDAKLSAA YPALW
//
