ID   G7GXW0_9ACTN            Unreviewed;      5927 AA.
AC   G7GXW0;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:GAB08435.1};
GN   ORFNames=GOARA_011_00510 {ECO:0000313|EMBL:GAB08435.1};
OS   Gordonia araii NBRC 100433.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1073574 {ECO:0000313|EMBL:GAB08435.1, ECO:0000313|Proteomes:UP000035088};
RN   [1] {ECO:0000313|EMBL:GAB08435.1, ECO:0000313|Proteomes:UP000035088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100433 {ECO:0000313|EMBL:GAB08435.1,
RC   ECO:0000313|Proteomes:UP000035088};
RA   Yoshida Y., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia araii NBRC 100433.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB08435.1}.
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DR   EMBL; BAEE01000011; GAB08435.1; -; Genomic_DNA.
DR   RefSeq; WP_007320513.1; NZ_JABELY010000018.1.
DR   STRING; 1073574.GOARA_011_00510; -.
DR   OrthoDB; 5475787at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000035088; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 2.
DR   CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR   CDD; cd19540; LCL_NRPS-like; 4.
DR   Gene3D; 3.30.300.30; -; 5.
DR   Gene3D; 3.40.50.980; -; 8.
DR   Gene3D; 1.10.1200.10; ACP-like; 4.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 5.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 5.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 5.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR   SUPFAM; SSF47336; ACP-like; 5.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 11.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 5.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          1266..1341
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2347..2422
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3414..3489
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4484..4559
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          5566..5641
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   5927 AA;  623949 MW;  BACE0A59CB4957F5 CRC64;
     MSAARTVHIR VPADVTEAVL GTAPEAFATG STEIMLAALA RAVRGYQRDA GIVDDRPVSV
     QVERHGRDDA VIAHSEGRAD LTRTVGWFTT IAPVLLDPAD DAVHAVKAAK EELAGQPDAG
     AGFGVLRYGA DSPLRQRPLP SIGFNFFGAG AAAGADTAPD LADELLPAAD GPVLPPSLSA
     RMRPANALTV NVSTVASDGG RELAADVGYD PAVLDEDEAA DLGRRWVDEL RAIVESVAAG
     DVGLSPSDVP GAQITQADLD DLAARYPGAA VWSLSPLQRG LYFQHELVAD ETDGLDVYAT
     QAVIGFEGKV DEARLRSAIA NVLARHRALR AGFVRAASGT VVAVIPSEVD PPVEVRDVSD
     DPDALDALAG AERLRPFDLA APPVIRFVLA RGTGSDSLVV TNHHILFDGW SGPLVLADLL
     SYYATGGPAI PGADVRPGAQ GDFADYLAQI AATDQATSIA AWRTALAGLD GPTLVGTGAG
     VDRDGLPEQE RSHLGPELTA RLAAMGRERQ VTVSTVLQAA WAVFLSRLTG NTTVCFGETV
     SGRPAQLDGV ETMIGLFINT LPVAVTVDPD QTVTELVDGM QRAKVDVLDH QHVSLAEIAG
     AVGEQVLFDT LTLHESYPID AESLENAAPA GDGLAVRDID MVDATHYPLN LYTAPIQGRE
     PGEQNETVAA DDVAVTFKYL PGEFSAAQIR AFAEVYFEIL RTMVADPDRR LRDIDPASEG
     LRREALDRAV GPVVEISRDT LPDGLAAQAA KTPTAVALRF GDREVTYREF AARVNTLARE
     LIALGVGPED AVAVCMPRSV EMLIALHAIV AAGGQYVPID TEAPPERTQY MLDTAGVALA
     LATDADIEPL RGTSARTVVV DAREPVDEAA ADTPIADVDR RSPLRPAHAA YTLFTSGSTG
     RPKGVTLSHE AVVNRLLWGN DEFGWGADDI VVQKTPYTFD CSVPELFAPF LVGAALVIAK
     PGGHADPLYL ADLVATTGAT SMHFVPSMLS VFNDIVGGVP GVRDGLASLR WIYTTGEALP
     PAVAARTREL IPGARFYNLY GPTEAAIEIT YEPVETVGDR IGIGVPVWNS TAYVLDEQLR
     PVPPGMPGEL YLGGVQLARG YAARPDLTAE RFVADPFAGT TTPSGESTPP GSLLYRTGDL
     VRILPGDDSA ADRLEYLGRT DFQVKLRGQR IELGEIESAI AGAPGVVHAA ATVVSAPGGA
     EHLVGYYAPA SADEGTVKAA VADALPEYMR PTLWVPLDDI VLNTAGKLDR NALPSPEFAA
     EAAFRAPSTP AEAAIADTFA DLLGLDEVSA DADFFDLGGN SLTATQLAGR LSALTGTRVG
     VRVLFESPTP AALAALLDLD GSAGRDDQPV AERSAELPLS LAQQRMWFLN TFDPDTTAFN
     LPLAMRLLGP LDDAAMAAAV HDVLERHEVL RTRYPATDDG GARQEIVDAD TAAAEVGYAR
     HTVADPIAAT AALCGQTFDV TRDIPIRIAV FAAPEGGEQV LAAVVHHIAA DGVSLGLIGT
     EVMTAYAARA AGTAPQWQPL PVQFADVALR QRERLGSLDD PQSELAKQYA YWLDALSGLP
     EVTEIPGDRA RPPVASMAGD TTYFTVPPEV VDGVRDVARS TGATDFMVVH AALAALIARL
     AGTADVVVGT PVAGRGDPET AGTVGMFVNT LVLRTPVDLA GDGEELVRAV RAVDSAALDN
     SEVPFEYLVE ALAPTRTEAH TPLFQIQLAF QNFAAGSDGA GGVAGLVVEP VRPPVTAVQN
     DLTFVLAPDG AGGWTGQLPY ATDLYDDETA QRLARRFVDL LAGLVAKPHL PVGDLPVLDD
     TERSEIERWS RGEDREVADD LIPEILAARA AAAPDSTALV FEGRTVSYGE FSTRVNTLAR
     ELIALGVGPE DAVAVCMPRS VEMLVALHGV IAAGGQYVPI DTTAPAERVE YMLDTVDAKL
     LLVRPDDTTH PVARAAAAGG ARVHPLDATA ATAPAAPVVD AERRAPLRPD HAVYTLFTSG
     STGRPKGVTL SHRAVLNRLW WGLDEIAWNA DDVIVQKTPY TFDCSVTELF APFLVGATLV
     VARPGGHADP RYLADLIATE RVTSVHFVPS MLAVFLDVVD DEQMARLTDL RHVSATGEAL
     PPAVAAEVLD RLDVDLWNLY GPTEAAVEIT YSKIGEVGDA IPIGKPVWNS TALVLDARLR
     PVPAGVPGEL YLGGVQLARG YAARGDLSAE RFVANPYGAP GERMYRTGDL VRWNTAGAGS
     EASGPIRHGE LEYLGRTDFQ VKLRGQRIEL GEIESVIAAA PGVVHAAATV VPGPGGTEHL
     VGYVSSAGGP AVDTEAVKAS VAASLPSYMV PTVWVALDDV VLNTAGKLDR NALPAPDFET
     VAAEFVTPAS PDETAVAGVF AEVLGVERVS VTESFFDLGG NSLSATKLAA RAGDALGADI
     AVRDVFEAPT VRDLVARMAG GAPVALPPVT AVEHRPHRIP LTNAQRRMWF INRFDPTLPT
     YNIPIGLRIG GDLDLDALRA AVDDVMARHE VLRTLFPDHD GVPYQLVLPA DDAADLVDWG
     VVEDDEALAT AAGTGFDLAE ELPIRIRLRQ VAATEHVLLV VVHHIAGDGH AGQVLARDLI
     GAYLARAAGT APTWSPLPVQ VADVAVWEEQ VLGAADDPGS VLGAELEFWR KTLEAAPDLL
     ELPTDFARPP VASMRGARTD FELSAATAGA VTRFAREHRV TPFMVVHAAL AALLARLAGT
     DDVAVGTPIA GRGRRELDDV VGMFVNTLVL RTEVDPRASF AELVDEVRRV DLDAFAHAHL
     PFEYLVTELA PVRSEAFAPF AQVLLTVEEG AGPQPGDETA GGLSLSPLDV GEVPAKVDLL
     VGVVTDPRDG QPWRGSIEYA TDLFTAETVA AFAARLEALL AGFTASPERP VGSAPLLNAA
     ERAELLPMRS GQGVAPVVLA DLFAAAAAEA PDVLAVVDGD GQRLTYGEID ERSNRLARWL
     IGRGVGADDL VALAIPRSAE LLVAVWAVAK TGAGYVPIDP DYPAQRRSTM VDDSGARVGL
     IAAGLDDNGD AGECRWVRFG AELDGELAGL SSSAIAPAER VRPVTAENLA YVIYTSGSTG
     KPKGVAVSHA GIANLAAAAA RDVSVPRAAR VLGFVSPSFD VSVFDYLVAT TARATLMYRP
     GPVVGGSELE RWIVDNRVEY GFLTPSVLAS LDPANTGSLR VLYAGGEAIS KSLVNRWAPH
     LELRNLYGPT EATIAATLSA PLRAADERVP LGAPVLGVEL LVLDSSLMPV PVGVSGELYL
     SGPGLARGYL GRSALTAERF VADPHGGAGR RMYRTGDVVR WMRDHDGALI LDYVGRSDHQ
     VKLRGLRIEV GEIETALTGA TGVAAAVVLG VNDTGVQSTG ESTGVTALAA YVVPERGAGL
     DPNDIRSEIA AGLPAYMVPS SITVIDELPM TPVGKLDTAA LPAPVFAAAD EHVVPQTTAE
     QAIAAVYADL LGVSRVGSTD SFFDLGGNSL SATRLVSRVG EVLGVEIGVR DVFEAPTVGE
     LAARVARATE AALPTVTRVQ SRPPALPLSF AQRRMWFINQ FSPGASAGYN VPLAVRLTAD
     AGGAGLDVAA MRAAVADVMA RQETLRTRFV QTADGEVVAV IADPARAAGE LDWLELAASS
     PDEATATAAD IVTRGFDVST DLPIRGAVIE LAPTDHIVVL VLHHIAADGQ SLTPLLDDLV
     RAYLARSAGR SPDFAPLPVD YVDYSLWQQR VLGDPDDPES RAAQQLAHWT GQLAGLPDVI
     TLPTDRRRPA VASMRGAAVD FTVDAQVRAA ARQLAAAHGT TEFAVTQAAV SALVARLSGT
     SDVAIGIPVA GRGQRELEPL VGMFVNTLVL RAEVESWDSF DALVDQASGV VVDALSHADV
     PFEHVVEALN PVRSESFAPL TQVFFTFEQN DPVDVDLGGL RVRGVDPGAT AAKVDLNFAL
     SVDARTDGYA GQLIYATDLF NEQTAAAIAG RFTALLGALV RSPHAAVGDH LILTDAERAH
     LAAQTAPVAD TEHADSSLVE RFAAAVAANP SATAVRAGAS ELRYRDLDRA SSAIAAALVE
     RGTRPGDLVG VATSRSTDLV ATILGILKAG AAYLPLDTTN PVERLRYIVD DAHPRAVVVD
     EHTADLPVWS TMPGSVAVLR VDELLDASPL PDPVALPSAA RAYVIYTSGS TGQPKGVEVT
     HRDVLVLLDT AQADFGFASD DVWTMFHSYA FDFSVWEMFG PLLTGGSVVV VDRDVARSPD
     EFLELLAAES VTVLSQTPSA FAQLALARRR RPAELSLRHV VFGGEELPFD LVRQWFDDNP
     ADTATLVNMY GITETTVHVS YRPLDAATVT GGEASLIGRP LRSLAIHILD DRLQPVPDGV
     VGEMYVAGGQ LAQGYLGRPG LTGTRFVANP FGPVGSRLYR TGDLARRVRG DIEYLGRGDS
     QVQLRGFRIE LGEVRSALLT VGTVRDAAVV ISGEGAGEML VGYVVTDDGT VDAAAVREAA
     ARLLPAYMVP SAIVALTALP LTANGKLDRR ALPKPEALPT AAVEAVGPRE EIVAAIFAEV
     LGVDEVGATD SFFDIGGNSL SATRVAARVS EALDTGVTVR DVFEAPTVRD LAARSGGAIA
     RGPLVAGTRP ELVPLAYAQQ RMWFLNQFDT SSPAYNIPVA LRVRGGVDTD ALHAALGDVV
     TRHEVLRTVY PTVDGAPVQR VLDAGTARSQ LDWAVVASAG EALELGSRGF DVTVDLPIRA
     RVAADVDGHV VMIVVHHIAS DAESMPVFTR DLIAAYVART GGSEPGWTPL PVQYADYAIW
     QREQLGDPAD DDSVLAGQTR YWAEKLAELP EVTDLPADRR RPAVADLSGA ALRFEFGPRR
     SAAVHRIARH TGTTPFMVLH AALAATVSRL ASTDDVAIGA AVAGRGQAEL DELIGMFVNT
     VVLRTQHRGS DTAEQLLGQV AQVAMDAFSH ADVPFEQVVE AVAPNRSTAH APLFQVGINY
     LAGEVRNDTA TGPSSIEVID EAPPIAKVDL HAAFTEAPAA ADRLLRGELT YATALFDEVT
     VAGFRDVFLT VLDAMTDDPA AVVADVDVLD ETDRAELVPV VGDRGGLEPA TAREIFARRT
     LDPARPAVIE GTRSLDYASF EALTNRLARE FIARGAGPES VVGVGLARSL EAAVLITAVL
     KAGGAYLPLD PALPPERLHH MVADANPLLI VVRPRDRAAF DFADADRIVT VGDLAPAPTA
     SITPSADLTP RALARHSDGP VAGGELRGRL DVDSLAYLVY TSGSTGLPKA VAVSQRGLAR
     LSQQHREWTG AAPGAGERAE SISPGAGDTR VLAVAAIGFD GAFFELFAAF GLGLTLVVAP
     ADVYAGDALV DVIVEHGVTH AVITPAVLAT MDPARVVSLR HLGTAGEAVA PEVVSRWADS
     SDREMFNGYG PTETTVSATG AVLAPGEPIR IGRPVPGMAA LVLDERLRPV GRGVVGELYL
     CGDKLARGYH GQHGLTAARF VANPYAADGS GERMYRTGDL VRWVGEPAQL EFVGRSDHQV
     KINGQRVELG EIDAALADQP GISSAVTIGV ADRHGRDRLV GYLVPETVAT IDTGAVLDAL
     RRRLPAYMVP AALVTVDELP LTVIGKLDRR RLPIPEFPDD AEGYEAPANA TERLVADVFA
     EVLDVDRVSV VQSFFDAGGN SLSATRVVGA LRERTDADIA LATLFADPTP RGVAAALTGA
     AGVANDVLIT LRADGSRPPI FCIHPAGGLA WFYGGFAPYI EDRPIYGLQD PHVVLDEPEA
     SSVEELAARY AREIRAVAPH GPYHLLGWSI GGYLAHAVAV ELQRAGESVA YLGLMDSIAL
     GGDVATDGSP EVDAHTEADA ADLLGGWREL FDLGDDVTAS SPEEVADVVR QQIAGMGLLD
     AGQVDRVMDS FANSAQIGAE YRPDVFDGSL QVFTATADKP DPAAVAASWR PYVTGGIANV
     DVDTHHLGMA DADALPVVGP ALQRGLDAVD RDVPRVRRSS NVKRRTT
//