ID G7J6M2_MEDTR Unreviewed; 1133 AA.
AC G7J6M2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:AES71604.1};
GN OrderedLocusNames=MTR_3g079790 {ECO:0000313|EMBL:AES71604.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES71604.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES71604.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES71604.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES71604,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES71604.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71604,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES71604}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71604};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; AES71604.1; -; Genomic_DNA.
DR RefSeq; XP_003601353.1; XM_003601305.2.
DR AlphaFoldDB; G7J6M2; -.
DR PaxDb; 3880-AES71604; -.
DR EnsemblPlants; AES71604; AES71604; MTR_3g079790.
DR Gramene; AES71604; AES71604; MTR_3g079790.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_2_1; -.
DR OMA; IFRTECE; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF588; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 81..247
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT COILED 194..221
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1133 AA; 128766 MW; B1CB783D45B27739 CRC64;
MTATSNDFLG SDLFMLDRMN ELRKVVEEPG ENGIDATYKE AKKKDYKALF CCGYCKALLT
MAMQLSIGSS SSSFARVVTP KEFDVFISFR GEDTRRNFTS HLYEALSKKV ITFIDDNELE
KGDEISSALI KAIEKSSASI VIFSKDYASS KWCLNELVKI LECKKDNGQI VIPVFYEIDP
SHVRNQKGSY MLAFEKHEQD LKQSKDKLQK WKDALTEAAN LAGWYSQNYK NDSIFIKYII
EDVLKKLNLR HPFEVNGHLF GIEEKYEEVK SLLKIGSNDV RGLGLWGMGG IGKTTLAKHL
YSKLCSQFDH HCLLENVSEE STRCGLKGVR NQLFSKLLEL RPDAPNLETT ISMRRLVCKK
SLIVLDDVAT LEQAENLNIV NNCLGPGSRV IVTTRDKQVC SQFNKCAIYE VKRLNKDESL
EVFCLEAFRE KYPKIGYGDL SKRAIGYCGG NPLGLKVLGT NFRTKSKEVW ESELEKLKKI
PNRRIHDVLK LSFDGLDCTQ QDIFLDIVCF FFLGKYIDRD FLTTLSDASN FFAESGIEVL
SNKALIVFRI CNLIDMHDLL VEMGREIVKQ QSPKNPGSRS RLWDPMEVCD TLKYKKGTEV
VEVIIFDISE IRDLYLTSDS FKSMTNLRCL HIFNKMQLPD EGKHYNVHFL QGLEWLSDKL
RHLYWVGFPL ESLPSTFSAE WLVRLEMRGS KLKKLWDGIQ KLGNLKSIDL CYSKDLIEMP
DLSRAPKLSL VSLDFCESLS KLHPSILTAP KLEALLLRGC KNIESLKTNI SSKSLRRLDL
TDCSSLVEFS MMSEKMEELS LIQTFKLECW SFMFCKSSGQ IRPSCLSLSR CKKLNIIGSK
LSNDLMDLEL VGCPQINTSN LSLILDELRC LRELNLSSCS NLEALPENIQ NNSKLAVLNL
DECRKLKSLP KLPASLTELR AINCTDLDID SIQRPMLENI LHKLHTIDNE GDRILDTNFG
FTFLPGDHVP DKFGFLTRES SIVIPLDPKC KLSALIFCII LSGRYGDYYE SVCCDCFQNG
KIIFNWDQVV SAEMLTEDHV LLSSFTEIWC FERLDWTMNE SEGDHCSISC EFMCRANEAE
EWSTDGIKGC GVLPVYSLES ESVELQPIVQ VSDGLQHREI GAEVGNDCGF FLV
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