ID G7JZI8_MEDTR Unreviewed; 1175 AA.
AC G7JZI8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=NB-ARC domain disease resistance protein {ECO:0000313|EMBL:AES98658.1};
GN OrderedLocusNames=MTR_5g071220 {ECO:0000313|EMBL:AES98658.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES98658.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES98658.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES98658.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES98658,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES98658.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES98658,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES98658}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES98658};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001221; AES98658.1; -; Genomic_DNA.
DR RefSeq; XP_003615700.1; XM_003615652.1.
DR AlphaFoldDB; G7JZI8; -.
DR EnsemblPlants; AES98658; AES98658; MTR_5g071220.
DR Gramene; AES98658; AES98658; MTR_5g071220.
DR HOGENOM; CLU_000837_8_8_1; -.
DR Proteomes; UP000002051; Chromosome 5.
DR ExpressionAtlas; G7JZI8; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF33; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 6..91
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 157..385
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1175 AA; 134010 MW; 2D31EFE347856C91 CRC64;
MADALLGVVL QNLKSLVQNE LATISGIKSK AQKLSTTLDL VNAVLEDAEQ KQVINRSIKV
WLQQLKDAVY VLDDILDECS IESARLIASS SFKPKNIIFC REIGKRLKEI TRRLDDIAES
KNKFHLGENG TFRERSIEVA EWRQTSSIIA EPKVFGREDD KEKIIEFLLT QARDSDFLSV
YPIVGLGGVG KTTLVQLVYN DARVSSNFNT KIWVCVSETF SVKRILCSII ESITREKYDG
FNLDVIQRKV QELLQGKIYL LILDDVWNKN QQLEFGLSQE KWNILKSVLS CGSKGSSILV
STRDEVVATI MGTCHAHPLY VLSDNECWLL FKQYAFGQNR EERAELVEIG KEIVKKCDGL
PLAAQALGGL MSSRNEEKEW LEIKESELWA LPHENYILPA LRLSYFHLTP TLKRCFAFCA
MFPKDTEFVR EELIHLWMAN EFILSRENME VEDVGSMVWN ELCQKSFFQD IKMDNGSGDI
SFKMHDLVHD LAQSVMGQEC MYLENSNMTT LSKSTHHISF HYDDVLSFDE GAFRKVESLR
TLFQLNHYTK TKHDYSPTNR SLRVLCTSFI QVPSLGSLIH LRYLELRSLE IKMLPDSIYN
LQKLEILKIK DCQKLSCLPK GLACLQNLRH LVIKDCHSLF HMFPYIGKLT CLRTLSVYIV
SLEKGNSLAE LHDLNLGGKL SIKGLNDVCS LSEAQAANLM GKKDLQELCF SWTSNDGFTK
TPTISFEQLF EVLQPHSNLK RLIICHYNRL FLPSWISILS NLVALVLWNC EKCVRLPSFG
KLQSLKKLAL HNMNDLKYLD DDEESQDGIV ARIFPSLEVL ILEILPNLEG LLKVERGEMF
PCLSRLTISF CPKLGLPCLV SLKNLDVLGC NNELLRSISS FCGLNSLTLA GGKRITSFPD
GMFKNLTCLQ ALDVNDFPKV KELPNEPFSL VMEHLIISSC DELESLPKEI WEGLQSLRTL
DICRCKELRC LPEGIRHLTS LELLTIRGCP TLEERCKEGT GEDWYKISNQ EAKMLVFLLP
FSDSEQLGVD ACIKLFDQFK SYAGLYFFLD AYLSSRNHFT QLLNRLLSDG RTGAIVIVAY
QILQCDAEHV LPIKIKILSS SYKSDMLWNV RNAAESRLFL CQTMLIDQVM STAFSESKRK
RMTSEDTNEK STVLFDNKVP FIFLFELWIL LSMRN
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