ID G7K2V5_MEDTR Unreviewed; 1228 AA.
AC G7K2V5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=NB-ARC domain disease resistance protein {ECO:0000313|EMBL:AES96281.1};
GN OrderedLocusNames=MTR_5g035280 {ECO:0000313|EMBL:AES96281.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES96281.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES96281.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES96281.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES96281,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES96281.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES96281,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES96281}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES96281};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001221; AES96281.1; -; Genomic_DNA.
DR RefSeq; XP_003613323.1; XM_003613275.1.
DR AlphaFoldDB; G7K2V5; -.
DR PaxDb; 3880-AES96281; -.
DR EnsemblPlants; AES96281; AES96281; MTR_5g035280.
DR Gramene; AES96281; AES96281; MTR_5g035280.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR OMA; EPRVWIC; -.
DR Proteomes; UP000002051; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF33; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1168..1195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 172..410
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1228 AA; 140431 MW; 049542879E18069E CRC64;
MAEAVIEVVL DNLSTLIQKE LGLFLGVDRE LKSLSSLLTT IKATLEDAEE KQFSNRAIKD
WLLKLKDAAH VLDDILDECA TKALEPEYKG FKYGPSQKVQ SSCLSSLNPK NVAFRYKIAK
KIKRIRERLD GIAEERSKFH LTEIVRERRC EVLDWRQTTS IITQPQVYGR DEDKSKIVDF
LVDDASSFED LSVYPIVGLG GLGKTTLAQI VFNHEKVVNY FELRIWVCVS EDFSLKRMTK
AIIESTSGHA CEDLELEPLQ RKLLNLLQRK RYLLVLDDVW DDDQENWQRL RFVLACGGKG
ASILVTTRLS KVAAIMGTMP FHDISMLSET DCWELFKQRA FGPTEAERSD LAVIGKEIVK
KCRGVPLAAK ALGSLLRFKR EEKEWRYVKE SKLWNLQGEN SVMPALRLSY LNLPVKLRQC
FAFCALFPKD EIISKQFVIE LWMANGFIPS NGMLEAEDIG NEAWNELYCR SFFQDTQTDD
FGQIVYFTMH DLVHDLAQSI TEEVCHITND SGIPSMSEKI RHLSICRRDF FRNVCSIRLH
NVESLKTCIN YDDQLSPHVL RCYSLRVLDF ERKEKLSSSI GRLKYLRYLN LSWGNFKTLP
ESLCTLWNLQ ILKLDYCQNL QKLPNSLVHL KALQRLYLRG CISLSSLPQH VRMLASLKTL
TQYVVGKKKG FLLAELGQMN LQGDLHIENL ERVKSVMDAA EANMSSKYVD KLELSWDRNE
ESQLQENVEE ILEVLQPQTQ QLRSLGVRGY TGSFFPEWMS SPTLKYLTSL QLVHCKSCLH
LPHLGKLPSL KSLTVSNMSH VKYLDEESCN DGIAGGFICL EKLVLVKLPN LIILSRDDRE
NMLPHLSQFQ IAECPKLLGL PFLPSLIDMR ISGKCNTGLL SSIQKHVNLE SLMFSGNEAL
TCFPDGMLRN LNSLKKIEIY SLSTLESFPT EIINLSAVQE IRITECENLK SLTDEVLQGL
HSLKRLSIVK YQKFNQSESF QYLTCLEELV IQSCSEIEVL HESLQHMTSL QSLTLCDLPN
LASIPDWLGN LSLLQELNIS QCPKLTCLPM SIQCLTALKH LSIYSCNKLE KRCKEKTGED
WPKIAHIQSL KCNFICVCIY YAFHSREKPF SHCMGPICIG DFLVPFGSNS RSSKPRFEAL
KRTCQSHRHT RGFNVCFQKC SVMEESSALL SLLELVIFSL VTTLSLCTTF IKVILFMTQP
TMILIEDLLG QEFRCKLHEW KVSARRKR
//
