ID G7L6K5_MEDTR Unreviewed; 954 AA.
AC G7L6K5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cysteine proteinase superfamily protein {ECO:0000313|EMBL:AES80262.1};
GN OrderedLocusNames=MTR_7g078630 {ECO:0000313|EMBL:AES80262.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES80262.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES80262.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES80262.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES80262,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES80262.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES80262,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES80262}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES80262};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001223; AES80262.1; -; Genomic_DNA.
DR RefSeq; XP_003624044.1; XM_003623996.1.
DR AlphaFoldDB; G7L6K5; -.
DR PaxDb; 3880-AES80262; -.
DR EnsemblPlants; AES80262; AES80262; MTR_7g078630.
DR Gramene; AES80262; AES80262; MTR_7g078630.
DR eggNOG; KOG1543; Eukaryota.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_309140_0_0_1; -.
DR OMA; HICLIRI; -.
DR Proteomes; UP000002051; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF38; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 706..750
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 766..954
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 954 AA; 107946 MW; 4EA58174DFEEC4C3 CRC64;
MAATDQTYLA EDVIDDFQCE ALRKHIVNTS GSIGRKVQRY FSSSNFLVYR LKMAHQIKHI
NKKLNKVAAD RHNFGLRIND SDNHVVKRRE LTHSHVIDSD VIGRENDKHK IIDLLLQDSD
HKILSVIPIV GIGGLGKTTL AKTVFNDKSL DETFPLKMWV CVSDDFELQH LLVKIINSAS
VSDSAPNVIH QANIKNLDVQ QLQSHLRNTL AGKKFFLVLD DVWNEDHVKW IEVKNLLQVG
DEGSKVLVTT RSHSIAEMMC TNTSYTLEGL SRKDSLSVFV KWAFKEGEDK KYPKLIEIGK
EIVQKCGGLP LWKFVRDNEI WNLPQKKDDI LPAIKLSFDQ LPSYLKRCFA CFSLFVKDFV
FSNNHVTVLW EALDLLPSPN KGKTLEDVDF VVFGNACAFK LHDLVHDLAL YVNHTFSIKS
NNIAFLNNLA SRFKFLRVLQ LTNSKYESLP RSIDKLKHLR YLNLQDNKEL KILPDSVCKL
QNLQSLNLGG CLKFETLPNG IGNLISLRQL HITAMQSDFP DKEIAKLTSL EFLSIHSCDN
LENLKSLPLH VIPNLDSLFI DNCNNLKLSL GHDNVIPKLL CIDSLPQLLS FPQSLQGCAD
TLHTLSIADC ENLEKLPEWS STFYLGKSKP IILELPPDVG DYSWVILNVL GVHSSYNDTD
SLCTTGSVGG ALDDKWQVER HEVAKWIFNS YNKKKTDVED KISERFEHWK TKYGVVYKDV
AEKKKHFEIF KHNVIYIESF NADSQSHAGF KRTTRTSSRH KNITDIPTNV YWRKRRAVTP
VKNQRGCGNI KRHFFLLLLR CWAFSTVAAI EGIQQITSGN LVSFSEQQLV DCVASNWTNG
CNGGNKIDAF KFNLENGGIA TEASYPYKGV KGNSKKVHHQ VQIKGYEQVP KNSEDSLLKV
VANQPVSVNI DMRGMLKFYS SGIFTGECGT KPNHAVTIVG YGTSNDCTKY CSVL
//
