ID G7MI02_MACMU Unreviewed; 242 AA.
AC G7MI02;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=tRNA selenocysteine 1-associated protein 1 {ECO:0000256|ARBA:ARBA00016598};
DE AltName: Full=tRNA selenocysteine-associated protein 1 {ECO:0000256|ARBA:ARBA00033477};
DE Flags: Fragment;
GN ORFNames=EGK_00465 {ECO:0000313|EMBL:EHH14523.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH14523.1};
RN [1] {ECO:0000313|EMBL:EHH14523.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH14523.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Involved in the early steps of selenocysteine biosynthesis
CC and tRNA(Sec) charging to the later steps resulting in the
CC cotranslational incorporation of selenocysteine into selenoproteins.
CC Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved
CC in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins
CC synthesis. {ECO:0000256|ARBA:ARBA00024717}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TRSPAP family.
CC {ECO:0000256|ARBA:ARBA00008920}.
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DR EMBL; CM001253; EHH14523.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MI02; -.
DR Proteomes; UP000013456; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12610; RRM1_SECp43; 1.
DR CDD; cd12612; RRM2_SECp43; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034510; SECp43_RRM2.
DR InterPro; IPR040434; TSAP1.
DR InterPro; IPR041085; TSAP1_C.
DR PANTHER; PTHR37457:SF2; TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR37457; TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF17654; Trnau1ap; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 3..86
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 96..175
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT NON_TER 242
FT /evidence="ECO:0000313|EMBL:EHH14523.1"
SQ SEQUENCE 242 AA; 27284 MW; 6E7436593B5E27AD CRC64;
MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV EFADLATAEK
CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV GDLTPDVDDG MLYEFFVKVY
PSCRGGKVVL DQTGVSKGYG FVKFTDELEQ KRALTECQGA VGLGAKPVRL SVAIPKASRV
KPVEYSQMYS YSYNQYYQQY QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA
LE
//
