ID G7MRW9_MACMU Unreviewed; 849 AA.
AC G7MRW9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
DE Flags: Fragment;
GN ORFNames=EGK_16062 {ECO:0000313|EMBL:EHH26163.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH26163.1};
RN [1] {ECO:0000313|EMBL:EHH26163.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH26163.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM001257; EHH26163.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MRW9; -.
DR Proteomes; UP000013456; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005459; TRPC3_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF8; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01644; TRPCHANNEL3.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 347..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..257
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH26163.1"
FT NON_TER 849
FT /evidence="ECO:0000313|EMBL:EHH26163.1"
SQ SEQUENCE 849 AA; 97468 MW; 0089D32E7050531C CRC64;
SMEGSPSLRR MTVMREKGRR QAVRGPAFMF NDRGTSLTAE EERFLDAAEY GNIPVVRKML
EESKTLNVNC VDYMGQNALQ LAVGNEHLEV TELLLKKENL ARIGDALLLA ISKGYVRIVE
AILNHPGFAA SKRLTLSPCE QELQDDDFYA YDEDGTRFSP DITPIILAAH CQKYEVVHML
LMKGARIERP HDYFCKCGDC MEKQRHDSFS HSRSRINAYK GLASPAYLSL SSEDPVLTAL
ELSNELAKLA NIEKEFKNDY RKLSMQCKDF VVGVLDLCRD SEEVEAILNG DLESAEPLEV
HRHKASLSRV KLAIKYEVKK FVAHPNCQQQ LLTIWYENLS GLREQTIAIK CLVVLVVALG
LPFLAIGYWI APCSRLGKIL RSPFMKFVAH AASFIIFLGL LVFNASDRFE GITTLPNITV
IDYPKQIFRV KTTQFTWTEM LIMVWVLGMM WSECKELWLE GPREYILQLW NVLDFGMLSI
FIAAFTARFL AFLQATKAQQ YVDSYVQESD LSEVTLPPEI QYFTYARDKW LPSDPQIISE
GLYAIAVVLS FSRIAYILPA NESFGPLQIS LGRTVKDIFK FMVLFIMVFF AFMIGMFILY
SYYLGAKVNA AFTTVEESFK TLFWSIFGLS EVTSVVLKYD HKFIENIGYV LYGIYNVTMV
VVLLNMLIAM INSSYQEIED DSDVEWKFAR SKLWLSYFDD GKTLPPPFSL VPSPKSFVYF
IMRIINFPKC RRRRLQKDIE MGMGNSKSRL NLFTQSNSRV FESHSFNSIL NQPTRYQQIM
KRLIKRYVLK AQVDKENDEV NEGELKEIKQ DISSLRYELL EDKSQATEEL AILIHKLSEK
LNPSMLRCE
//
