ID G7MTM9_MACMU Unreviewed; 76 AA.
AC G7MTM9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Heat shock factor-binding protein 1 {ECO:0000256|ARBA:ARBA00039223};
DE Flags: Fragment;
GN ORFNames=EGK_16017 {ECO:0000313|EMBL:EHH26125.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH26125.1};
RN [1] {ECO:0000313|EMBL:EHH26125.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH26125.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC affects HSF1 DNA-binding activity. May have a role in the suppression
CC of the activation of the stress response during the aging process.
CC {ECO:0000256|ARBA:ARBA00037689}.
CC -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC trimers and HSP70 coincides with attenuation of heat shock response and
CC the conversion of HSF1 trimer to monomer.
CC {ECO:0000256|ARBA:ARBA00038772}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSBP1 family.
CC {ECO:0000256|ARBA:ARBA00006349}.
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DR EMBL; CM001257; EHH26125.1; -; Genomic_DNA.
DR AlphaFoldDB; G7MTM9; -.
DR Proteomes; UP000013456; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 1.20.5.430; -; 1.
DR InterPro; IPR009643; HS1-bd.
DR PANTHER; PTHR19424; HEAT SHOCK FACTOR BINDING PROTEIN 1; 1.
DR PANTHER; PTHR19424:SF3; HEAT SHOCK FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF06825; HSBP1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH26125.1"
FT NON_TER 76
FT /evidence="ECO:0000313|EMBL:EHH26125.1"
SQ SEQUENCE 76 AA; 8481 MW; F49F736ABF2E63BF CRC64;
IAETDPKTEQ ELTSVVQTLL QQIQDKFQTM SDQIIGRIDD MSSCIDDLKK NIADLMTQAG
VEELEGENEI PATQEV
//
