ID G7N8H0_MACMU Unreviewed; 299 AA.
AC G7N8H0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=BPTI/Kunitz inhibitor domain-containing protein {ECO:0000259|PROSITE:PS50279};
DE Flags: Fragment;
GN ORFNames=EGK_04610 {ECO:0000313|EMBL:EHH21520.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH21520.1};
RN [1] {ECO:0000313|EMBL:EHH21520.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH21520.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001264; EHH21520.1; -; Genomic_DNA.
DR AlphaFoldDB; G7N8H0; -.
DR MEROPS; I02.012; -.
DR Proteomes; UP000013456; Chromosome 12.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd22613; Kunitz_TFPI1_1-like; 1.
DR CDD; cd22614; Kunitz_TFPI1_2-like; 1.
DR CDD; cd22615; Kunitz_TFPI1_TFPI2_3-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 3.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008296; TFPI-like.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR PANTHER; PTHR10083:SF328; TISSUE FACTOR PATHWAY INHIBITOR; 1.
DR Pfam; PF00014; Kunitz_BPTI; 3.
DR PIRSF; PIRSF001620; TFPI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 3.
DR SUPFAM; SSF57362; BPTI-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 3.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..299
FT /note="BPTI/Kunitz inhibitor domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003500893"
FT DOMAIN 54..104
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 125..175
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 217..267
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT SITE 64..65
FT /note="Reactive bond"
FT /evidence="ECO:0000256|PIRSR:PIRSR001620-1"
FT SITE 135..136
FT /note="Reactive bond"
FT /evidence="ECO:0000256|PIRSR:PIRSR001620-1"
FT SITE 227..228
FT /note="Reactive bond"
FT /evidence="ECO:0000256|PIRSR:PIRSR001620-1"
FT NON_TER 299
FT /evidence="ECO:0000313|EMBL:EHH21520.1"
SQ SEQUENCE 299 AA; 34360 MW; 65487FD12D066AC5 CRC64;
MIYTMKKVHA LWVSICLMLN LAPAPLNADS EEDEEYTIIT DTELPPLKLM HSFCAFKPDD
GPCKAIMKRF FFNIFTRQCE EFIYGGCGGN QNRFESMEEC KKVCTRGRFL GTLITQDPLE
KPDFCFLEED PGICRGYITR YFYNNQSKQC ERFKYGGCLG NMNNFETLEE CKNTCEDGLN
GFQVDNYGTQ LNAVNNSQTP QSTKVPSFFE FHGPSWCLAP ADRGLCRANE NRFYYNSVIG
KCRPFKYSGC GGNENNFTSK RECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEV
//
