ID G7NFD5_MACMU Unreviewed; 292 AA.
AC G7NFD5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Rho guanine nucleotide exchange factor 39 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGK_07569 {ECO:0000313|EMBL:EHH23993.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH23993.1};
RN [1] {ECO:0000313|EMBL:EHH23993.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH23993.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001267; EHH23993.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NFD5; -.
DR Proteomes; UP000013456; Chromosome 15.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR042987; ARHGEF39.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47056; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR PANTHER; PTHR47056:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 22..182
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 184..288
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 292 AA; 33689 MW; E4676C3C55CFC056 CRC64;
MEIHYPGVRS PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFLG ILKAKGTLRP
PERQALFGSW ELIYGASQEL LPYLEGGCWG QGLEGFCRHL ELYNQFAANS ERSQTTLQEQ
LKKNKGFRRF VRLQESRPEF GGLQLQDLLP LPLQRLQQYE NLVVALAENT GPNSPDHQQL
TRRWFLRQGW LLVVPPHGEP RPRMFFLFTD VLLMAKPRPP LHLLQSGTFA CKALYPMAQC
QLSRVFGHSG GPCGGLLSLS FPHEKLLLMS TDQEELSRWY HSLTWAISSQ KN
//
