ID G7NR54_MACMU Unreviewed; 2571 AA.
AC G7NR54;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGK_13040 {ECO:0000313|EMBL:EHH31885.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:EHH31885.1};
RN [1] {ECO:0000313|EMBL:EHH31885.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR-5 {ECO:0000313|EMBL:EHH31885.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; CM001272; EHH31885.1; -; Genomic_DNA.
DR Proteomes; UP000013456; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22831; Gal_Rha_Lectin_PKD1L2; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF134; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 2; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 2.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2571
FT /note="Polycystic kidney disease protein 1-like 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003501349"
FT TRANSMEM 1388..1407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1595..1616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1636..1657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1868..1892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1904..1935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1993..2015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2258..2278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2298..2315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2347..2367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2387..2416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2485..2510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..153
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 161..252
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 422..1143
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1432..1549
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1664..1690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2544..2571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2571 AA; 284807 MW; C526EA77929B54AF CRC64;
MSAVGLVLLV LALRLRVATA KPEEGSFCSK SQVAFRDACY EFVPIGRTFR DAQSWCEGQG
GHLVFIQDED TQRFLQKHIS QDREWWIGLM WNLARNGTME GPGIWLDTSN VTYSNWRGGQ
ATAAPDTCGH IGRGPSSEWV ASDCAQTFAF VCEFRLGQSL ACKGLNATMH CGSGQVIQVQ
DAVYGRQNPY FCTQDAGHPS DLEQGCSWAN VKDEVAGQCQ GLQACQVAAD ETYFGNLCPT
QGSYLWVQYQ CWEALQLMVS SESFIFDNVT ISLTWLLSPY IGNLSCIIST GDGHIFDPYN
PPSVSSNVTH QFTSPGEFTV FAECTTSEWH VTAHRQVTVR DKMERLSVTA CSGLSQSGAG
PLCQAVFGDP LWIQVELDGG TGVTYTVLSG DITLAESTAQ RGSLPYNLTL DTETQKLMGP
GRHRLEIQAT SSTTSSALSG NITVHLVELL SGLQASWASD HLELGQDLLI NISVAQGTPE
ELTFEVAGLN ATFSHEQVSF GEPFGIYRLA IPVEGTFLVT MLVKNAFSNL SLEIGNITIT
GKKDKGDMEV SIQPGAYVDP FTTVTLDWPD NDKELRFQWS CGRCWAQWSG CVERQLLLTD
QRKLVVPASC LPPPDSAVTL RLAVRRGQEL ENRAERCLYV SAPWELRPRV SCERNCRPVN
ASEDILLRVT MVEDSPVAMF SWYLDNTSAE QAEPLPDACG LRGFWPSSLT LLQSNTSTLL
LNSSFLRSWG EVIRIRATAL TRHAYGEDTY VISALPPAEV PACTVAPEEG TVLTSFAIFC
NASTALGPLE FCFCLESGSC LHCGPEPVLP SVYLPLGKEN NDFVLTVVIS ATNRAGDTQQ
TQAVAKVALG DTWVEDVAFQ AAVSEKISTS LQGEGGPKQL LQLAKAVSSV LNQEHKSQGS
GQPLSMDVRQ KGLHVAIWAM HQGSWIGEKP VVSPKRLTPP PSLFFWVREH VLGSLSTVTA
SLEDMQRVQE LAEVLREVTR RSRELTPSAQ WEASWALQHA SESLLTVSAK ARPEDQRRQA
ATRDLFQAVG SVLEASLSDR PEELAEASGS QSATVLRLLG VVEHVQTALL LGKLPGGLPA
VLATPSISVY TNRIQPWSWQ GSSLRTDTAD SATFMLPTAS LLGSLEDGQE PVDIKGRLSA
ASALTLETCQ GKQRQRKMMS FPKSPFPARS HFDVSGTVGG LRVTSPSGQL IPMKNLSENI
EILLPRHSQG HSQPTVLNLT SPEALWVNVT SGEATLGIQL HWRPDIALTL SLGYGYHPNK
SSYDAQTYLV PTAASDELPT WILSPQDLHF GEGVYYLTVV PESDLEPVPG RDLTVGITTF
LSHCVFWDEV QEAWDDSGCQ VGPRTSSYQT HCLCNHLTFF GSTFLVMPNA IDIHQTAELF
ATFEDNPVIV TTVGCLCLVY VLVVIWARRK DAQDQAKVKV TVLEDNDPFA QYHYLVTVYT
GHRRGAATSS KVTVTLYGLD GESEPHHLSD PDTPVFERGA VDAFLLSTLF PLGELRSLRL
WHDNSGDRPS WYVSRVLVYD LAMDRKWYFL CNSWLSINVG DCVLDKVFPV ATEQDRKQFS
YLFFMNTSAG FQDGHIWYSI FSRCARSSFT RVQRVSCCFS LLLCTMLTSI MFWGVPKDPA
EQKMDLGKIE FTWQEVMIGL ESSILMFPIN LLIVQIFRNA RPRVTKEQNT EKRDQGSPNL
TPSPQPVEDG LLTPEAVTKA GPQPQLDVSR IVSSLFKALK LPSPSSGWDS VNLMDINSLL
ALVEDVICPQ NTSGQVFWEE AKMREDPVTL TVGSSQMKEK TQCPKPKAAW SGPWNDSPYR
QYLYLQLEHV EQGLQLVGPR GFPQHHSHAR ALRQLQTLKG CLGVQPGTWT PAHASALRVS
KPPQGLPWWC ILVGWLLVAA TSGVAAFFTM LYGLHYGRAS SLRWLISIAV SFVESVFVTQ
PLKVLGFAAF FALVLKRVDD EEDTVALLPG HLLGPDPYAL FRARRNSSRD VYQPPLTAAV
EKMKTTHLKE QKAFALIREI LAYLGFLWML LLVAYGQRDP SAYHLNRHLE HSFTRGFSGV
LGFREFFEWA NTTFVSNLYG HPPGFITDGN SKLVGSAQIR QVRVRESSCP LAQQLQASLN
GCRAPYSLDA EDLADYGEGW NATALGNGSS FPHAWQYQSQ DQRRGYPIWG KLTVYRGGGY
VVPLGTDRQS TSRILRYLFD NTWLDALTRA VFVEFTVYNA NVNLFCIVTL TLETSALEAM
ALREQVAPSE QNALCSPGTF FTHTALQSLR LYPFTDGWHP FVVAAELIYF LFLLYYMVVQ
GKRMRKQTWS YFRSKWNLLE LAIILASWSA LAVFVKRAVL AERDLQRCRN HREEAVSFSE
TAAADAALGY IIAFLVLLST GKLWHLLRLN PKMNMITAAL RRAWGDISGF IIVIVTMLLA
YSIALCLSVT AALTAFHPRR HPIFLSHPRK QVGCTDGVMG SNLMFGWKLR SYKTLFDAAE
TMISLQLGIF NYEEVLDHSP VLGSFLIGSC IVFMTFVVLN LFVSVILVAF SEEQKYYQLS
EEGEIVDLLL MKIFSFLGIK CKREEPESSR EQPGSLSQTR RSQPAQALPK V
//
