ID   G7NU47_MACFA            Unreviewed;      1334 AA.
AC   G7NU47;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
DE   Flags: Fragment;
GN   ORFNames=EGM_01681 {ECO:0000313|EMBL:EHH50800.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000313|EMBL:EHH50800.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH50800.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
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DR   EMBL; CM001276; EHH50800.1; -; Genomic_DNA.
DR   eggNOG; ENOG502QPPT; Eukaryota.
DR   Proteomes; UP000009130; Chromosome 1.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF32; ADENYLATE CYCLASE TYPE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          66..143
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EHH50800.1"
FT   NON_TER         1334
FT                   /evidence="ECO:0000313|EMBL:EHH50800.1"
SQ   SEQUENCE   1334 AA;  155018 MW;  F1AAA6EB00289A5A CRC64;
     QIDDKQLQGY LSELRPVTIV FVNLMFEDQD KAEEIGPAIQ DAYIHITSVL KIFQGQINKV
     FMFDKGCSFL CVFGFPGEKV PDELTHALEC AMDIFDFCSQ VHKIQTVSIG VASGIVFCGI
     VGHTVRHEYT VIGQKVNIAA RMMMYYPGIV TCDSVTYNGS NLPAYFFKEL PKKVMKGVGD
     SGPLYQYLGR TEKVMFGMAC LICNRKEDYP LLGRNKEINY FMCIMKKFLM SNSSQVLMYE
     GLPGYGKSQI LTKIEYLAQG ENHRVIAISL TKISFHQTFY TIQMLMVNVL GLDTCKHYKE
     RQTNLQNKVM TLLDEKFYCL LNDIFHVQFP ISREISRMST LKKQNQLEVL FMKILEQTVK
     EEWIIFIIHE AQFVDSTSWR FMEKLIRTLP IFIIMSLCPF VDIPCAAASA IMKNRNTTYI
     TVGAVQPNDI TNKICLDLNV SCIPKELDLY LVEGSCGIPF YCEELLKNLE HHKVLVFQQT
     ESEEKTNRTW NNLFKYFIKP IERLNMVTLQ SDEESEVCHL ASGVRLKNLS PPTSLKEISL
     IQLDSMSLSH QMLVRCAAII GLTFTTELLF EILPCWNMKM MIKALATLVE SNIFHCFRNG
     KELQNALKQN DTSFEVHYRS LSLKPSEGMD HGEEEELREL ENEVIECHRI RFCSPMMQKT
     AYELWLKDQR KAMHLKCARF LEEDAHRCDH CRSKDFIPYH HFTVNIRLNT LDMDAIKKMA
     TSHGFGTQED LILSKSEIPE TSALFPENPS PDKIREKILN FFDDVLTKMK TSDEDIIPLE
     SCQCEEILEI VILPLAHHFL ALGENNKALY YFLEIASAYL ILHDNYMAYV YLNEGEKLLK
     TLEKDKAGSQ TFESATFYSL KGEVCFNMGQ IALAKKMLRK ALKLLNRIFP YNLISLFLHI
     RIEKNRHFHY VNQQAQDSPP PGKKRLAQLY RQTVCLSLLW RIYSYSYFFH WKYYAQLAVM
     MQMNTALETQ NHFQIIKAYL DYSLYHHLAG YQGVWFKYEV MAMEQIFNLP LKGEGIEIVA
     YVAETLVFNK FIMGHLDLAI ELGSRALQMW ALLQNTNQHY LSLCRLSRCL LLNSRYPQLI
     QVLGRLWELS ETQEHVLSKA FFYFICLDIL LYSGFVYRTF EECLEFVYQY EDNRILKFQS
     GLLLGLYSSV AIWYARLQEW DNFYIFSNRA KNLLPRRTMT PIYCDGISRY MEGQILHLQK
     QIKEQSDNAQ ASGEELLKNL ENLVAQNTTG PVFCPRLYHL MAYICILMGD GQKCGVFLNT
     ALRLSETQGN MLEKCWLNMS KEWWYSTSEL KEEQWFQTIL SLPSWEKIVA GRVNIQDLQK
     NKFQMRANTV DNHF
//