ID G7NZP4_MACFA Unreviewed; 1239 AA.
AC G7NZP4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE RecName: Full=Interphotoreceptor matrix proteoglycan 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_10299 {ECO:0000313|EMBL:EHH50988.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH50988.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH50988.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix {ECO:0000256|ARBA:ARBA00004593}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CM001277; EHH50988.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NZP4; -.
DR eggNOG; ENOG502QT6W; Eukaryota.
DR Proteomes; UP000009130; Chromosome 2.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR039861; IMPG.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR12199; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN; 1.
DR PANTHER; PTHR12199:SF4; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2; 1.
DR Pfam; PF01390; SEA; 2.
DR SMART; SM00200; SEA; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50024; SEA; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1101..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 238..352
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 898..1011
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1011..1052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 177..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1020..1037
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1239 AA; 138267 MW; 0F64FF7AC235ACE7 CRC64;
MIMFPLFGKI SLGILIFVLI GDFPSLTAQT YLSLEEIQEP KSAVSFLLPE ESTDLSLATK
KKQPLDLRET ERQWLLRRRR SILFPNGVKI CPDESVTEAV ANHVKYFKVR VCQEAVWEAF
RTFWDRLPGR EEYHYWMNLC EDGVTSIFEM GTNFSESVEH RSLIMKKLTY AKETVSSPEL
SSPVPVGDTS TLGDTALSVP HPGVDSYEGA SDSSLERPEE SISNEIENVI EEATKPAAEQ
IAEFSIHLLG KEYREELQDS SSFHHQHLEE EFISEVENAF TGLPGYKEIR VLEFRSPKEN
DSGVDVYYAV TFNGEAISNT TWDLISLHSN KVENHGLVEL DDKPTVVYTI SNFRDYIAET
LQQNFLLGNS SLNPDPDSLQ LINVRGVLRH QTEDLVWNTQ SSSLQATPSS ILDNTFQAAW
PSADESTTSS IPPLDFSSGP PSATGRELWS ESPLGDLVST HKLAFPSKMG LSSSPEVLEV
SSLTLHSVTP AVLQTGLPVA SEERTSGSHL VEDGLANVEE SEDFLSIDSL PSSSFTQPVP
KETIPSMEDS DVSLTSSPYL TSSIPFGLDS LTSKVKDQLK VSPFLPDASM EKELILDSGL
GSGSGQKVDL ITWPWSETSS EKSTEPLSKP WLEDDDSLLP AEIEDEKLVL VDKMDSTDQI
SKHSKYEHDD RSTHFPEEEP LSGPAVPIFA DTATESASLT LPKHISEVPG VDDYSVTKAP
LILTSVAISA STEISDQADA ILREDTEQTT ESSNYEWFDS EVSMVKPDMQ PLWTILPESE
RVSTRTSSLE KLSRDTLAST PQSTDRLWLK ASVTQSTKLP PTTISTLLED EVIMGVQDIS
LELDRIGTDY YQPELVQEQN GKVGSYVEMS TSVHSTEMVS VAWPTEGGDD LSYTQTSGAL
VVFFSLRVTN MMFSEDLFNK NSLEYKALEQ RFLELLVPYL QSNLTGFQNL EILNFRNGSI
VVNSRMKFAN SVPPNVNTAV YMILEDFCTA AYNTMNLAID KYSLDVESGD EANPCKFQAC
NEFSECLVNP WSGEAKCRCF PGYLSVEERP CQSLCDLQPD FCLNDGKCDI MPGHGAICRC
RVGENWWYRG KHCEEFVSEP VIIGITIASV VGLLVIFSAI IYFFIRTLQA HHDRSERERP
FSGFSRQPDS LSSIENAVKY NPVYKSHRTG CEKYEGPYPQ HPFYSSASGD MIGGLSREEI
RQMYESSELS REEIQERMRV LELYANDPEF AAFVKEQQV
//
