ID G7P7E2_MACFA Unreviewed; 829 AA.
AC G7P7E2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN ORFNames=EGM_14999 {ECO:0000313|EMBL:EHH54213.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH54213.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH54213.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001281; EHH54213.1; -; Genomic_DNA.
DR AlphaFoldDB; G7P7E2; -.
DR eggNOG; ENOG502QTTQ; Eukaryota.
DR Proteomes; UP000009130; Chromosome 6.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd11867; hSH3_ADAP; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043443; FYB1/2-like.
DR InterPro; IPR035540; FYB_hSH3.
DR InterPro; IPR029294; hSH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR16830:SF13; FYN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR16830; SH2 CONTAINING ADAPTOR PRAM-1 RELATED; 1.
DR Pfam; PF14603; hSH3; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 511..572
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 746..814
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..364
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..427
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 90891 MW; 8F6C7E531612284A CRC64;
MAKFNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSSVPKFGSP
KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPANLTT RDPEAKVGFP KPVGPKPINL
PKEDSKPAFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TLENEQKQAF PKLAGVKGKF
MSASQDLESK PLFPKPAFGQ KPPLSTENSH EEESPVKNVS PSKGSPAPLG VRSKSGPLKP
AREDPENKDH AGEISSSPFP GVVLKPVASR GGPGLSKNGE EKKEDRKIDA AKNTFQGKTN
QEDSASGAPP SRFPKAPSKL RVEGPWSQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP
NRPPHVDLTK FLKTSSGNST SKGQTSYSTT SPPPPPPSHP ASQPPLPASH PSQPPVPSLP
PRNIKPPFDL KNPVNEDNQD GVMHSDGHYY HWSEQESEGE TYEDIEASKE REKKREKEEK
KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII
RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE
QDNISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGSTLQ VQEKSNTWSW GILKMLKGKD
DKKKSIREKP KVSESDNNEG SSFPAPPKQL DMGDEVYDDV DTSDFPISSA EMSQGANIGK
AKTEEKDLKK LKKQEKEEKD FRKKFKYDGE IRVLYSTNVT TSVTSKKWGT RDLQVKPGES
LEVIQNTDDT KVLCRNEEGK YGYVLRSYLA DNDGEIYDDI ADGCIYDND
//
