ID G7P9B2_MACFA Unreviewed; 1691 AA.
AC G7P9B2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=ADAMTS-like protein 3 {ECO:0000313|EMBL:EHH63287.1};
GN ORFNames=EGM_16223 {ECO:0000313|EMBL:EHH63287.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH63287.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH63287.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001282; EHH63287.1; -; Genomic_DNA.
DR eggNOG; KOG3538; Eukaryota.
DR Proteomes; UP000009130; Chromosome 7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 12.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF169; ADAMTS-LIKE PROTEIN 3; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 11.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00209; TSP1; 12.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 12.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 10.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1691
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003502030"
FT DOMAIN 896..992
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1185..1279
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1296..1378
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1655..1691
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 1153..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 87..118
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 91..123
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 102..108
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 1691 AA; 188779 MW; 40EC85CBEC70E722 CRC64;
MASWTSPWWL LIGMVFMHST LQETTAEKSP GAYFLPEFAL SPQGSFLEDT TGEQFLTYRY
DDQTSRNTHS DEDKDGNWDA WGDWSDCSRT CGGGASYSLR RCLTGRNCEG QNIRYRTCSN
HDCPPDAEDF RAQQCSAYND VQYQGHYYEW LPRYNDPAAP CALKCHARGQ NLVVELAPKV
LDGTRCNTDS LDMCISGICQ AVGCDRQLGS NAKEDNCGVC AGDGSTCRLV RGQSKSHVSP
EKREENVIAV PLGSRSVRIT VKGPAHLFIE SKTLQGSKGE HSFNSPGVFV VENTTVEFQR
GSERQTFKIP GPLMADFIFK TRYTAAKDSV VQFFFYQPIS HQWRQTDFFP CTVTCGGGYQ
LNSAECVDIR LKRVVPDHYC HYYPENVKPK PKLKECSMDP CPSSDGFKEI MPYDHFQPLP
RWEHNPWTAC SVSCGGGIQR RSFVCVEESM HGEILQVEEW KCMYAPKPKV MQTCNLFDCP
KWIAMEWSQC TVTCGRGLRY RVVLCINHRG EHVGGCNPQL KLHIKEECVI PIPCYKPKEK
SPVEAKLPWL KQAQELEETR IATEEPTFIP DPWSACSTTC GPGVQVREVK CRVLLTFTQT
ETELPEEECE GPKLPTERPC LLEACDESLA SRELDIPLPE DSEMTYDWEY AGFTPCTATC
LGGHQEAIAV CLHIQTQQTV NDSLCDMVHR PPAMSQACNT EPCPPRWHMG SWGPCSATCG
VGIQTRDVYC LHPGETPAPP EECRDEKPHA LQACNQFDCP PGWHIEEWQQ CSRTCGGGTQ
NRRVTCRQLL TDGSFLNLSD ELCQGPKASS HKSCARTDCP PHLAVGDWSK CSVSCGVGIQ
RRKQVCQRLT AKGRLVPLSE MMCRDLPGLP LVRSCQTPEC SKIKSEMKTK LGEQGPQILS
VQRVYIQTRE EKRINLTIGS RAYLLPNTSV IIKCPVRRFQ KSLIQWEKDG RCLQNSKRLG
ITKSGSLKIH SLATPDIGVY RCIAGSAQET VVLKLIGTDN RLIARPALRE PMREYPGMDH
NEANSLGVTW HKMRQMWNNK NDLYLDDDYI SNQPFLRALL GHCSSSAGNT NSWELKNKQF
EAAVKQGAYS MDTAQFDELI RNMSQLMETG EVSDDLASQL IYQLVAELAK AQPTHMQWWG
IQEEMPPAAQ LRGETGSVSQ SSNAKNSGKL TFKPKGPVLM RQSQPPSISF NKTINSRIGN
TVYITKRTEV INILCDLITP GEATYTWTKD GTLLQPSVKI ILDGTGKIQI QNPTRKEQGT
YECSVANHLG SDVESSSVLY AEAPVILSIE RNITKPEHNH LSVMVGGIVE AALGANVTIR
CPVKGVPQPN ITWLKRGGSL SGNVSLLFNG SLLLQNVSLE NEGTYVCTAT NALGKAVATS
VLHLLERRWP ESKIVFPQGH KKYVLQATNT RTNSNDPTGE PLPQEPFWEP GNWSRCSATC
GHLGARIQRP QCVMANGQEV SEALCDHLQK PLAGFQPCNI RDCPARWFTS MWSQCSVSCG
EGYHSRQVMC KQTKANGTVQ VVSPRACAPK DRPLGRKPCF GHPCVQWEPG NQCPGRCMGH
AMRMQQHHTA CQHNGSDSNC DDRRRPALRR NCTSGACDVC WHAGPWKPCT AACGRGLQSR
KVDCIHTRSC KPVAERHCVQ KKKPVSWRHC LGPSCDRDCT DKTHYCMFVK HLNLCSLDLY
KQRCCQSCQE G
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