ID   G7PBK5_MACFA            Unreviewed;      1002 AA.
AC   G7PBK5; A0A2K5UUI6;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   Name=RNF111 {ECO:0000313|Ensembl:ENSMFAP00000016084.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000016084.1, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000016084.1, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000016084.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
CC   -!- SIMILARITY: Belongs to the Arkadia family.
CC       {ECO:0000256|ARBA:ARBA00007622}.
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DR   RefSeq; XP_005559721.1; XM_005559664.2.
DR   RefSeq; XP_005559722.1; XM_005559665.2.
DR   AlphaFoldDB; G7PBK5; -.
DR   STRING; 9541.ENSMFAP00000016084; -.
DR   Ensembl; ENSMFAT00000066614.2; ENSMFAP00000016084.1; ENSMFAG00000031221.2.
DR   GeneID; 102127303; -.
DR   KEGG; mcf:102127303; -.
DR   CTD; 54778; -.
DR   VEuPathDB; HostDB:ENSMFAG00000031221; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   GeneTree; ENSGT00940000157691; -.
DR   OrthoDB; 5474929at2759; -.
DR   Proteomes; UP000233100; Chromosome 7.
DR   Bgee; ENSMFAG00000031221; Expressed in cerebellum and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16681; RING-H2_RNF111; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR029306; RNF111_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR16200:SF1; E3 UBIQUITIN-PROTEIN LIGASE PLR-1-RELATED; 1.
DR   PANTHER; PTHR16200; RING ZINC FINGER; 1.
DR   Pfam; PF15303; RNF111_N; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          950..991
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   1002 AA;  109760 MW;  CA0414E3AA75D1A2 CRC64;
     MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP AGVEMINSKV
     GNEFSHLCDD SQKQEKDMNG NQQEQEKSVV VRKKRKSQQA GPSYVQNCVK ENQGILGLRQ
     HLGAPSDEDN DSSFSDCLSS PSSSLHFGDS DTVTSDEDKE VPVRHSQTIL SAKSRSHSAR
     SHKWPRTETE SVSGLLMKRP CLHSSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE
     VLARRKYALL PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNSA VPSGSIDEDV
     VVIEASSTPQ VTANEEINVT STDSEVEIVT VGEGYRSRST LGHSRSHWSQ GSSSHASRPQ
     EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA RMESQATSAS INNSNPSTSE
     QASDTASAVT SSQPSTVSET SATLTSNSTT GTSIGDDSRR TTSSAVTETG PPAMPRLPSC
     CPQHSPCGGS SQNHHALGHP HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE
     RPPQVQAPCG ANSSSGTSYH EQQALPVDLS NNGIRSHGSG SFHGASAFDP CCPVSSSRAA
     IFGHQAAAAP SQPLSSMDGY GSSMVAQPQP QPPPQPSLSS CRHYMPPPYA SLTRPLHHQA
     SACPHSHGNP PPQTQPPPQV DYVIPHPVHA FHSQISSHAT SHPVAPPPPT HLASTAAPIP
     QHLPPTHQPI SHHIPATAPP AQRLHPHEVM QRMEVQRRRM MQHPTGLFVF CVSRRAHERP
     PPHPHRMHPN YGHGHHIHVP QTMSSHPRQA PERSAWELGI EAGVTAATYT PGALHPHLAH
     YHAPPRLHHL QLGALPLMVP DMAGYPHIRY ISSGLDGTSF RGPFRGNFEE LIHLEERLGN
     VNRGASQGTI ERCTYPHKYK KVTTDWFSQR KLHCKQDGEE GTEEDTEEKC TICLSILEEG
     EDVRRLPCMH LFHQVCVDQW LITNKKCPIC RVDIEAQLPS ES
//