ID G7PCH2_MACFA Unreviewed; 845 AA.
AC G7PCH2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Low-density lipoprotein receptor-related protein 12 {ECO:0000313|EMBL:EHH64358.1};
DE Flags: Fragment;
GN ORFNames=EGM_17549 {ECO:0000313|EMBL:EHH64358.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH64358.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH64358.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CM001283; EHH64358.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PCH2; -.
DR Proteomes; UP000009130; Chromosome 8.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF47; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Lipoprotein {ECO:0000313|EMBL:EHH64358.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Receptor {ECO:0000313|EMBL:EHH64358.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..845
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003501982"
FT DOMAIN 33..145
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 245..358
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 609..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 152..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 171..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 225..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 381..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 419..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 437..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 444..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 456..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH64358.1"
FT NON_TER 845
FT /evidence="ECO:0000313|EMBL:EHH64358.1"
SQ SEQUENCE 845 AA; 93240 MW; 950D78B4ECC9AA1E CRC64;
SWILVYSLCL ILGNGALAEH SENVHISGVS TACGETPEQI RAPSGIITSP GWPSEYPAKI
NCSWFIRANP GEIITISFQD FDIQGSRRCS LDWLTIETYK NIESYRACGS TIPPPYISSQ
DHIWIRFHSD DSVSRKGFRL AYFSGKSEEP NCACDQFRCG NGKCIPEAWK CNNMDECGDS
SDEEICAKEA NPPTATAFQP CAYNQFQCLS RFTKVYTCLP ESLKCDGNID CLDLGDEIDC
DVPTCGQWLK YFYGTFNSPN YPDFYPPGSN CTWLIDTGDH RKVILRFTDF KLDGTGYGDY
VKIYDGLEEN PHKLLRVLTA FDSHAPLTVV SSSGQIRVHF CADKVNAARG FNATYQVDGF
CLPWEIPCGG NWGCYTEQQR CDGYWHCPNG RDEINCTMCQ KEEFPCSRNG VCYPRSDRCN
YQNHCPNGSD EKNCFFCQPG NFHCKNNRCV FESWVCDSQD DCGDGSDEEN CPVIVPTRVI
TAAVIGSLIC GLLLVIALGC TCKLYSLRMF ERRSFETQLS RVEAELLRRE APPSYGQLIA
QGLIPPVEDF PVCSPNQASV LENLRLAVRS QLGFTSVRLP MAGRSSNIWN RIFNFARSRH
SGSLALVSAD GDEVVPSQST SREPERNHTH RSLFSVESDD TDTENERRDT AGASGGVAAP
LPQKVPPTTA VEATVGACAS SSTQSTRGGH ADNGRDVTSV EPPSVSPARH QLTSALSRMT
QGLRWVRFTL GRSSSVSQNQ SPLRQLDNGV SGREDDDDVE MLIPVSDGSS DFDVNDCSRP
LLDLASDQGQ GLRQPYSATN PGVRPSNRDG PCERCGIVHT AQIPDTCLEV TLKNETSDDE
ALLLC
//
