ID G7PGG1_MACFA Unreviewed; 1014 AA.
AC G7PGG1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 03-MAY-2023, entry version 35.
DE SubName: Full=PRb1 {ECO:0000313|EMBL:EHH65367.1};
DE Flags: Fragment;
GN ORFNames=EGM_02115 {ECO:0000313|EMBL:EHH65367.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH65367.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH65367.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; CM001285; EHH65367.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PGG1; -.
DR eggNOG; KOG1010; Eukaryota.
DR Proteomes; UP000009130; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20605; CYCLIN_RBL1; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF20; RETINOBLASTOMA-LIKE PROTEIN 1; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 17..159
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 332..525
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 747..856
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 898..1014
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH65367.1"
FT NON_TER 1014
FT /evidence="ECO:0000313|EMBL:EHH65367.1"
SQ SEQUENCE 1014 AA; 115285 MW; 8986F81EC06429D3 CRC64;
EVTHWLACSL YVACRKSIIP TVGKGIMEGN CVSLTRILRS AKLSLIQFFS KMKKWMDMSN
LPQEFRERIE RLERNFEVST VIFKKYEPIF LDIFQNPYEE PPKLLRSRKQ RRIPCSVKDL
FNFCWTLFVY TKGNFRMIGD DLVNSYHLLL CCLDLIFANA IMCPNRQDLL NPSFKGLPSD
FHTADFRASE EPPCIIAVLC ELHDGLLVEA KGIKEHYFKP YISKLFDRKI LKGECLLDLS
SFTDNSKAVN KEYEEYVLTV GDFDERIFLG ADAEEEIGTP RKFTGDTPLG KLTAQANVEY
NLQQHFEKKR SFAPSTPLTG RRYLREKEAV ITPVASATQS VSRLQSIVAG LKNAPSDQLT
NIFESCVRNP MENIMKILKG MGETFCQHYT QSTDEQPGSH IDFAVNRLKL AEILYYKILE
TVMVQETRRL HGMDMSVLLE QDIFHHSLMA CCLEIVLFAY SSPRTFPWII EVLNLQPFYF
YKVIEVVIRS EEGLSRDMVK HLNSIEEQIL ESLAWSHDSA LWEALQVSAN KVPTCEEVIF
PNNFETGNGG NVQGHLPMMP MSPLMHPRVK EVRTDSGSLR RDMQPLSPIS VHERYSSPTA
GSAKRRLFGE DPPKEMLMGK IITEGTKLKI APSSSITAEN VSILPGQTLL TMATAPLTGT
TGHKVIIPSH GVANDAAEIT LPISMNTNQE SKVKSPVSLT AHSLIGASPK QTSLTKAQEV
HSTGISRPKR TGSLALFYRK VYHLASVRLR DLCLKLDVSN ELRRKIWTCF EFTLVHCPDL
MKDRHLDQLL LCAFYIMAKV TKEERTFQEI MKSYRNQPQA NSHVYRNVLL KSIPREFVAY
NKNINDDFEM IDCDLEDATK TPDCSSGPVK EERGDLIKFY NTIYVGRVKS FALKYDLSNQ
DHVMDAPPLS PFPHIKQQPG SPRRISQQHS IYISPHKNGS GLTPRSTLLY KFNGSPSKSL
KEINNMIRQG EQRTKKRVIA IDSDAESPAK RVCQENDDVL LKRLQDVVSE RANH
//
