ID G7PLN4_MACFA Unreviewed; 907 AA.
AC G7PLN4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=GEN1 Holliday junction 5' flap endonuclease {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_04579 {ECO:0000313|EMBL:EHH55379.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH55379.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH55379.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CM001288; EHH55379.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PLN4; -.
DR eggNOG; KOG2519; Eukaryota.
DR Proteomes; UP000009130; Chromosome 13.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09905; H3TH_GEN1; 1.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041012; GEN_chromo.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR Pfam; PF18704; Chromo_2; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT DOMAIN 1..96
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 122..193
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 817..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 102676 MW; D83520680A072BA1 CRC64;
MGVNDLWQIL EPVKQHIPLR NLGGKTIAVD LSLWVCEAQT VKKMMGSVVK PHLRNLFFRI
SYLTQMDVKL VFVMEGEPPK LKADVISKRN QTRYGSSGKS WSQKTGRSHF KSVLRECLDM
LECLGIPWVQ AAGEAEAMCA YLNAGGHVDG CLTNDGDTFL YGAQTVYRNF TMNTKDPHVD
CYTMSTIKSK LGLDRDALVG LAILLGCDYL PKGVPGVGKE QALKLIQILK GQSLLQRFNR
WNETSCNSSP QPLVTKKLAH CSVCSHPGSP KDHERNGCRL CKSDKYCEPH DYEYCCPCDW
HRTEHDRQLS EVENNMKKKA CSCEGFPFHE VIQEFLLNKD KLVKVIRYQR PDLLLFQRFT
LEKMEWPNHY ACEKLLVLLT RYDMIERKLG SRNSNQLQPI RIVKTRIRNG VHCFEIEWEK
PEHYAMEDKQ HGEFALLTIE EESLFEAAYP EIVAIYQKQK LEIKGKKQKR IKPKENNLPE
PDEVMCFQSH MTLKPTCEIF HKQNSKLKLG ISPDSALPQE SISASLNSLL LPKTTPCLNV
QEQFMSSPRP LAIQIKAVSK SLISESSQPS TSSRNISVIA DLHLSTIDWE GTSFSTSPAI
QRNTFSHGLK SEVESELSAI PGGFENIPEQ LSCESERYTA NIQKVLDEDS DRISPEEHLL
SGITDLCLQD LPLKERIFIK SSYPQDSLQP DVNLKTLSIL SVKEPYIANS GSDCTSHLSK
DLPGIPLQNE SRDSKVLKGD QLLQENYKVN TSAPYSISNT VVKTCNVRPP NTALDHSRKV
DMQTTQKILM KKSVCLNRHS SDEQSAPVFG RAKYTTQRMK HSSQKQNTTQ FKESGHNKLG
SPKIHIKESE QCVRSYKTAE NEESCFPDSA KSSLSSLQCH KKETNSVTCL DSPLPLRQRL
KLRFQST
//
