ID G7PQV1_MACFA Unreviewed; 440 AA.
AC G7PQV1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Integrin-linked protein kinase {ECO:0000256|ARBA:ARBA00015063};
DE AltName: Full=59 kDa serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00032103};
DE AltName: Full=Beta-integrin-linked kinase {ECO:0000256|ARBA:ARBA00031016};
DE AltName: Full=ILK-1 {ECO:0000256|ARBA:ARBA00030970};
DE AltName: Full=ILK-2 {ECO:0000256|ARBA:ARBA00030969};
DE AltName: Full=p59ILK {ECO:0000256|ARBA:ARBA00029809};
GN Name=ILK {ECO:0000313|Ensembl:ENSMFAP00000036186.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000036186.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000036186.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000036186.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR AlphaFoldDB; G7PQV1; -.
DR SMR; G7PQV1; -.
DR Ensembl; ENSMFAT00000010430.2; ENSMFAP00000036186.2; ENSMFAG00000034446.2.
DR VEuPathDB; HostDB:ENSMFAG00000034446; -.
DR eggNOG; KOG0195; Eukaryota.
DR GeneTree; ENSGT00940000155956; -.
DR OrthoDB; 2127408at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000034446; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd14057; PK_ILK; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035692; PK_ILK.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR23257:SF967; INTEGRIN-LINKED PROTEIN KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000654; Integrin-linked_kinase; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT REPEAT 21..53
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 54..86
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 87..119
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 181..434
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 440 AA; 50142 MW; AF09C0F630BF453A CRC64;
MDKLVSWRFV VQIISSPRDD HGFSPLHWAC REGRSAVVEM LIMRGARINV MNRGDDTPLH
LAASHGHRDI VQKLLQYKAD INAVNEHGNV PLHYACFWGQ DQVAEDLVAN GALVSICNKY
GEMPVDKAKA PLRELLRERA EKMGQNLNRI PYKDTFWKGT TRTRPRNGTL NKHSGIDFKQ
LNFLTKLNEN HSGELWKGRW QGNDIVVKVL KVRDWSTRKS RDFNEECPRL RIFSHPNVLP
VLGACQSPPA PHPTLITHWM PYGSLYNVLH EGTNFVVDQS QAVKFALDMA RGMAFLHTLE
PLIPRHALNS RSVMIDEDMT ARISMADVKF SFQCPGRMYA PAWVAPEALQ KKPEDTNRRS
ADMWSFAVLL WELVTREVPF ADLSNMEIGM KVALEGLRPT IPPGISPHVC KLMKICMNED
PAKRPKFDMI VPILEKMQDK
//
