ID G7PRZ4_MACFA Unreviewed; 1016 AA.
AC G7PRZ4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=EGM_06856 {ECO:0000313|EMBL:EHH57260.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH57260.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH57260.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone.
CC Has guanylate cyclase activity upon binding of its ligand. May play a
CC role in the regulation of skeletal growth.
CC {ECO:0000256|ARBA:ARBA00043880}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; CM001290; EHH57260.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PRZ4; -.
DR eggNOG; KOG1023; Eukaryota.
DR Proteomes; UP000009130; Chromosome 15.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06384; PBP1_NPR_B; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF508; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00458; ANF_RECEPTORS; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Receptor {ECO:0000313|EMBL:EHH57260.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 482..755
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 830..960
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH57260.1"
FT NON_TER 1016
FT /evidence="ECO:0000313|EMBL:EHH57260.1"
SQ SEQUENCE 1016 AA; 113972 MW; 7F1C97A5B96866E7 CRC64;
PEHNLSYAWA WPRVGPAVAL AVEALGRALP VDLRFVSSEL EGACSEYLAP LSAVDLKLYH
DPDLLLGPGC VYPAASVARF ASHWRLPLLT AGAVASGFSA KNDHYRTLVR TGPSAPKLGE
FVVTLHGHFN WTARAALLYL DARTDDRPHY FTIEGVFEAL QGSNLSVQHQ VYAREPGGPE
QATHFIRANG RIVYICGPLE MLHEILLQAQ RENLTNGDYV FFYLDVFGES LRAGPTRATG
RPWQDNRTRE QAQALREAFQ TVLVITYREP PNPEYQEFQN RLLIRAREDF GVELGPSLMN
LIAGCFYDGI LLYAEVLNET IQEGGTREDG LRIVEKMQGR RYHGVTGLVV MDKNNDRETD
FVLWAMGDLD SGDFQPAAHY SGAEKQIWWT GRPIPWVKGA PPSDNPPCAF DLDDPSCDKT
PLSTLAIVAL GTGITFIMFG VSSFLIFRKL MLEKELASML WRIRWEELQF GNSERYHKGA
GSRLTLSLRG SSYGSLMTAH GKYQIFANTG HFKGNVVAIK HVNKKRIELT RQVLFELKHM
RDVQFNHLTR FIGACIDPPN ICIVTEYCPR GSLQDILEND SINLDWMFRY SLINDLVKGM
AFLHNSIISS HGSLKSSNCV VDSRFVLKIT DYGLASFRST AEPDDSHALY AKKLWTAPEL
LSGNPLPTTG MQKADVYSFG IILQEIALRS GPFYLEGLDL SPKEIVQKVR NGQRPYFRPS
IDRTQLNEEL VLLMERCWAQ DPAERPDFGQ IKGFIRRFNK EGGTSILDNL LLRMEQYANN
LEKLVEERTQ AYLEEKRKAE ALLYQILPHS VAEQLKRGET VQAEAFDSVT IYFSDIVGFT
ALSAESTPMQ VVTLLNDLYT CFDAIIDNFD VYKVETIGDA YMVVSGLPGR NGQRHAPEIA
RMALALLDAV SSFRIRHRPH DQLRLRIGVH TGPVCAGVVG LKMPRYCLFG DTVNTASRME
SNGQALKIHV SSTTKDALDE LGCFQLELRG DVEMKGKGKM RTYWLLGERK GPPGLL
//
