ID G7PUJ7_MACFA Unreviewed; 2360 AA.
AC G7PUJ7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=EGM_07819 {ECO:0000313|EMBL:EHH58046.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH58046.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH58046.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; CM001291; EHH58046.1; -; Genomic_DNA.
DR eggNOG; KOG4418; Eukaryota.
DR Proteomes; UP000009130; Chromosome 16.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR CDD; cd00054; EGF_CA; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF7; G-PROTEIN COUPLED RECEPTOR 179-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..2360
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003502778"
FT TRANSMEM 378..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..651
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 695..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1497..1517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1811..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..1946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2116..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2298..2345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1595..1637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1898..1915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2360 AA; 257017 MW; 752EE8E7D99B6B8A CRC64;
MGTRGAVMPP TVWGLLGCCF ICDWALGGPR PLRSLPPLSS QVKPGSVPMR VPPEGAEAAV
TYLYSGDAQQ LSQANCSERY EARGAGAMPG LPPILQGAAG TLAQAANFLN MLLQANDIRE
SSVEEDVEWY QALVRSMAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPRADGY VGNTQQVRLS PPFLECQEER
LRPGWLITLS ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
QCVPLESQGF VLGRYLCRCR PGFYGASPSE GLEESAFQTT GQFGSPEGRS GRLLRCLPCP
EGCTSCMDAT PCLVEEAVAL RAAVLACQAC CMLAIFLSML VSYRCRRNKA RIWASGVVLL
ETVLFGFLLL YFPVFILYFK PSVFRCIALR WVRLLGFAIV YGTIILKLYR VLQLFLSRTA
QRSALLSSGR LLRRLGLLLL PVLGFLAVWT VGALERGIQH APLVIRSHTP TGRHFYLCHH
DRWDYIMVVA ELLLLCWGSF LCYATRAVLS AFHEPRYMGI ALHNELLLST AFHTARFVLV
PSLHPDWTLL LFFFHTHSTV TTTLALIFIP KFWKLGAPPR EEMVDEVCED ELDLQHSGSY
LGSSIASAWS ERSLDPGDIR DELKKLYAQL EVHKTKEMAA NNPHLPKKRG SSRQGLGRSF
MRYLAEFPEA LARQHSRDSG SPGRGSLPGS SRRRLLSSSL QEPEGTPALR KSRSTYDQRR
EQDPPLLDSL LRRKLAKKAS RTESRAVEGP PALGFRSASA HNLTVGERLP RARPASLQKS
LSVAGSREKA LLMASQAYLE ETYRQAKERE ERKKAEAAMA SLVRRPSARR LERPRGAPLS
APPSPAKSSS MDSSHASGRL HEEAGRRLPH PPIRHQVSTP TLTLSGTCLG EPGMLSPTST
LAPALLPALA PTPVPAPAPV PVPPQSPNLL TYICPWENAE LPVKKENVPQ EGPSGPEQGH
HSPAPARARL WRALSVAVEK SKPGENEMDA EDAHHQREAN DVDEDRPKIF PKSHSLKAPV
QQGSMRSLGL AIKALTRSRS TYREKERVEE SPKGQNSGTV GESVGAPSRS PRLGRPKAVS
KQAALAPCDD EESLQNQQNA HTSRMLQVCQ QEGSREQEDR GRRTSQGLGE QKAERAGKTG
LAALRQVSRD KNVKQSKDAP VGWQELPKIG IQSLGSVDHR VAEVCPWEVT ESETRQPDSG
NKAEICPWEM SEGAPESRSL RQDPGDSQEK SGEARGKSEP TDVVPMMRKK PDRLVREQEA
VCPWESADQG GLCPGSAPQD PGRIRDKSEV GGSVEARKVE KPGWEAAGSE AHTSDIAKAE
LCPWEASEGG EDGKPALEVV KDLPQEKQKT RKATFWKEQK PGGDLESLCP WESTDFRGPS
AVSIQAPGSS ECSGSLGSGI AEVCPWEAGD APAIRKAEIC PWELDDNVMG QEMLSLGTGG
ESLQKEKASR KGSFGEMGEH TVKAVQKLSQ QQESVCPRES TVPGPSSPCL DNSSSKAGGQ
FLRNGGSRAT QVCPQEDLRP EAQEATPAKA EICPWEVNER TREEWTSAQA PRRGDSQKDK
EKMPGKSEIK DVTAWEKPEG QIQKQEAVSP WESVNPGSFS PQPHPQDTER PQTLLQISGS
VGSKAADICS LDVEETLTAG KAEICPWEVG AGAGEERALG AEAIRVSPND TGKVFADLGP
RETAVTVPEK PQKPTPEWDV ACPWGSVGPD TLDADGPKAG FQELDHMGCR PGEVCPWEAQ
EAATSEKAKM CPWEVNEGTT GKGLDQETGS ESAEQREKAL EKGRLTSLGE DASKRMAKLC
QEQEAICLWE NKNLRESPAQ APKISDLPSS MRSEVAEGHS LEATEKADLR QDPKVGSFPE
HITQEKAPAP NTEEFTTEDG EKTSHELQSV YTWVTTAPAV SFSHPNRQRP DQPKASSQRL
VSTGGRAADV CPWDVPDAGV YKPDRSAKAE TCPWEVTERI PVKGVSRQDG KGDSQEEKGR
APEKSEPKGV PVQKKPEMAD FRQQEAVCPW ESQHGKDLSP QPAPDASDSN RGSSEAAGSV
ETRVVEVCLW EVEEAPSAKK AEISPWEVGG GAAEERELER ESQGQGEMFL QKAGPGGTEE
HFSKAAAKPR EQEVVCLGEG TGSGGLLPQS GALDPELKVS PEGAGSMGSR MAELCQWEIT
DPEGNKIKGT MADICPGEET GVPPEESGLL ALTATQREFF PTAPEKPLCL LVHGPLDHFF
PESKIPCPKV SRPASTFTLE GVRELQGPSG LEPRTSLAPE PSLQEAEAQS SSLTEDSGQV
AFEAQYEEFT PPTVYPWDWE
//
