ID G7PUQ2_MACFA Unreviewed; 422 AA.
AC G7PUQ2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE SubName: Full=Cytokeratin-23 {ECO:0000313|EMBL:EHH58101.1};
GN ORFNames=EGM_07885 {ECO:0000313|EMBL:EHH58101.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH58101.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH58101.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; CM001291; EHH58101.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PUQ2; -.
DR eggNOG; ENOG502QTH0; Eukaryota.
DR Proteomes; UP000009130; Chromosome 16.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF44; KERATIN, TYPE I CYTOSKELETAL 23; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 72..382
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 168..202
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 326..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 48004 MW; 2B62F706BA30FB50 CRC64;
MNSRSSFSQT PSASFHGTGD GWGRPRSFPR APTVHGGAAG TRISLSFTTR SCPPAGGSWG
SGRSSPLLGG NGKATLQNLN DRLASYLEKV RALEEANMKL ESRILKWHQQ RDPGSKKDYS
QYEESITHLQ EQIVDGKMTN AQIILLIDNA RMAVDDFNLK YENEHSFKRD LEIEVEGLRR
TLDNLTIVTT DLEQEVEGMR KELILMKKRH EQEMEKHHVP SDFSVNVKVD TGPKEDLIKV
LEDMRQEYEL IIKKKHQDLD TWYKEQSAAM SQEAASPAAV QSRQGDIHEL KRTFQALEID
LQAQYSTKSA LENLLSETQS RYSCKLQDMQ EIISHYEEEL MQLRHDLERQ NNEYQVLLGI
KTHLEKEITT YRRLLEGESG GTMEESKSSM KASATPKIKA ITQETVNGRL VLCQVNEIQK
HA
//
