ID G7PV56_MACFA Unreviewed; 962 AA.
AC G7PV56;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=EGM_08059 {ECO:0000313|EMBL:EHH58255.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH58255.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH58255.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; CM001291; EHH58255.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PV56; -.
DR SMR; G7PV56; -.
DR eggNOG; KOG1027; Eukaryota.
DR Proteomes; UP000009130; Chromosome 16.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF17; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 556..817
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 820..948
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH58255.1"
FT NON_TER 962
FT /evidence="ECO:0000313|EMBL:EHH58255.1"
SQ SEQUENCE 962 AA; 108211 MW; 4510DF06A96ED2B5 CRC64;
SLQIFGSTST VTLPETLLFV STLDGSLHAV SKRTGSIKWT LKEDPVLQVP THVEEPAFLP
DPNDGSLYTL GSKNNEGLTK LPFTIPELVQ ASPCRSSDGI LYMGKKQDIW YVIDLLTGEK
QQTLSSAFAD SLCPSTSLLY LGRTEYTITM YDTKTRELRW NATYFDYAAS LPEDDMDYKM
SHFVSNGDGL VVTVDSESGD VLWIQNYASP VVAFYVWQRE GLRKVMHINV AVETLRYLTF
MSGEVGRITK WKYPFPKETE AKSKLTPTLY VGKYSTSLYA SPSMVHEGVA VVPRGSTLPL
LEGPQTDGVT IGDKGECVIT PSTELKFDSG LKSKNKLNYL RNYWLLIGHH ETPLSASTKM
LERFPNNLPK HRENVIPADS EKKSFEEVIN LVDQTSENAP TTVSRDVEEK PAHAPARPEA
PVDSMLKDVA TIILSTFLLI GWVAFIITYP LSMHQQQQLQ HQQFQKELEK IQLLQQQQQQ
LPFHPPGDTA QDGELLDTSG PYSESSGTSS PNTSPRASNH SLCSGSSASK AGSSPSLEQD
DGDEETSMVI VGKISFCPKD VLGHGAEGTI VYRGMFDNRD VAVKRILPEC FSFADREVQL
LRESDEHPNV IRYFCTEKDR QFQYIAIELC AATLQEYVEQ KDFAHLGLEP ITLLQQTTSG
LAHLHSLNIV HRDLKPHNIL ISMPNAHGKI KAMISDFGLC KKLAAGRHSF SRRSGVPGTE
GWIAPEMLSE DCKENPTYTV DIFSAGCVFY YVISEGSHPF GKSLQRQANI LLGACSLECL
HPEKHEDVIA RELIEKMIAM DPQKRPSAKH VLKHPFFWSL EKQLQFFQDV SDRIEKESLD
GPIVKQLERG GRAVVKMDWR ENITVPLQTD LRKFRTYKGG SVRDLLRAMR NKKHHYRELP
AEVRETLGSL PDDFVCYFTS RFPHLLAHTY RAMELCSHER LFQPYYFHRP PEPQPPVTPD
AL
//
