ID G7PZP0_MACFA Unreviewed; 485 AA.
AC G7PZP0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Cytochrome P450 4F8 {ECO:0000313|EMBL:EHH59310.1};
GN ORFNames=EGM_09388 {ECO:0000313|EMBL:EHH59310.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH59310.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH59310.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CM001294; EHH59310.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PZP0; -.
DR eggNOG; KOG0157; Eukaryota.
DR Proteomes; UP000009130; Chromosome 19.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20679; CYP4F; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF192; CYTOCHROME P450 4F8; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461}.
SQ SEQUENCE 485 AA; 56388 MW; CCB1D9DC39622D20 CRC64;
MWTYTFYDNC RRLRCFPQPP KQNWFLGHLG LVTPTEEGLR VLTQLVATYP QGFVKWMGPI
FPVINLYHPD TIRSVINTSD AITDKDVVFY KMLKPWLGDG LLLSAGDKWR HHRRMLTPAF
RFNILKPYIK IFNKSTNIMH AKWQRLALEG STRLDMFEHI SLMALDSLQK CIFSIDSHCQ
EKPSEYIAAI MEISALIVKR NHKFFLYKDF LYFLTPCGRR FLRACRLVHD FTDAVIQERR
RTLPSQGVDD FLQAKAKSKT LDFIDVLLLS KDKNGKELSD EDIRAEADTF MFGGHDTTAS
GLSWVLYNLA RHPEYQERCR QEVQELLKDR EPKEIEWDDL AQLPFLTMCL KESLRLYPPV
PTITRGCTQD VVLPDSRVIP KGNICSINIF AMHHNPSVWP DPEVYDPFRF DPENIQKRSP
MAFIPFSAGP RNCIGQSFAM AEIKVVLALT LLRFRILPDH REPRRTPEII LRAEDGLWLR
VEPLG
//
