ID G7Q155_MACFA Unreviewed; 558 AA.
AC G7Q155;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=E3 ubiquitin-protein ligase AMFR {ECO:0000313|EMBL:EHH60393.1};
DE Flags: Fragment;
GN ORFNames=EGM_11747 {ECO:0000313|EMBL:EHH60393.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH60393.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH60393.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM001295; EHH60393.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Q155; -.
DR eggNOG; KOG0802; Eukaryota.
DR Proteomes; UP000009130; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd14421; CUE_AMFR; 1.
DR CDD; cd16455; RING-H2_AMFR; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040675; AMFR_Ube2g2-bd.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15067:SF4; E3 UBIQUITIN-PROTEIN LIGASE AMFR; 1.
DR PANTHER; PTHR15067; E3 UBIQUITIN-PROTEIN LIGASE RNF8; 1.
DR Pfam; PF02845; CUE; 1.
DR Pfam; PF18442; G2BR; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00546; CUE; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..294
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 371..413
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT REGION 419..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH60393.1"
FT NON_TER 558
FT /evidence="ECO:0000313|EMBL:EHH60393.1"
SQ SEQUENCE 558 AA; 63808 MW; 6C1237A56AF70991 CRC64;
VLVNTACCVL MLVAKLIQCI VFGPLRVSER QHLKDKFWNF IFYKFIFIFG VLNVQTVEEV
VMWCLWFAGL VFLHLMVQLC KDRFEYLSFS PTTPMSSHGR VLSLLVAMLL SCCGLAAVCC
ITGYTHGMHT LAFMAAESLL VTVRTAHVIL RYVIHLWDLN HEGTWEGKGT YVYYTDFVME
LTLLSLDLMH HIHMLLFGNI WLSMASLVIF MQLRYLFHEV QRRIRRHKNY LRVVGNMEAR
FAVATPEELA VNNDDCAICW DSMQAARKLP CGHLFHNSCL RSWLEQDTSC PTCRMSLNIA
DNNRVREDHQ GENLDENLVP VAAAEGRPRL NQHNHFFHFD GSRIASWLPS FSVEVMHTTN
ILGITQASNS QLNAMAHQIQ EMFPQVPYHL VLQDLQLTRS VEITTDNILE GRIQVPFPTQ
RSDSIRPALN SPVERPSSGQ EEGETSAQTE RVPLDLSPRL EETLDFGEVE VEPSEVEDFE
ARGSRFSKSA DERQRMLVQR KDELLQQARK RFLNKSSEDD AASESFLPSE GASSDPVTLR
RRMLAAAAER RLQKQQTS
//
