ID G7VFA0_9CREN Unreviewed; 152 AA.
AC G7VFA0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Riboflavin synthase {ECO:0000256|ARBA:ARBA00013950};
DE EC=2.5.1.9 {ECO:0000256|ARBA:ARBA00012827};
GN ORFNames=P186_0256 {ECO:0000313|EMBL:AET31716.1};
OS Pyrobaculum ferrireducens.
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=1104324 {ECO:0000313|EMBL:AET31716.1, ECO:0000313|Proteomes:UP000005867};
RN [1] {ECO:0000313|EMBL:AET31716.1, ECO:0000313|Proteomes:UP000005867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1860 {ECO:0000313|EMBL:AET31716.1,
RC ECO:0000313|Proteomes:UP000005867};
RX PubMed=22247528; DOI=10.1128/JB.06465-11;
RA Mardanov A.V., Gumerov V.M., Slobodkina G.B., Beletsky A.V.,
RA Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.;
RT "Complete genome sequence of strain 1860, a crenarchaeon of the genus
RT pyrobaculum able to grow with various electron acceptors.";
RL J. Bacteriol. 194:727-728(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC ChEBI:CHEBI:58201; EC=2.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000968};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}.
CC -!- SIMILARITY: Belongs to the DMRL synthase family.
CC {ECO:0000256|ARBA:ARBA00007424}.
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DR EMBL; CP003098; AET31716.1; -; Genomic_DNA.
DR AlphaFoldDB; G7VFA0; -.
DR STRING; 1104324.P186_0256; -.
DR KEGG; pyr:P186_0256; -.
DR eggNOG; arCOG01322; Archaea.
DR HOGENOM; CLU_1682776_0_0_2; -.
DR OrthoDB; 23911at2157; -.
DR BioCyc; PSP1104324:GJSN-248-MONOMER; -.
DR UniPathway; UPA00275; UER00405.
DR Proteomes; UP000005867; Chromosome.
DR GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR InterPro; IPR002180; LS/RS.
DR InterPro; IPR036467; LS/RS_sf.
DR InterPro; IPR006399; Ribfl_synth_arc.
DR NCBIfam; TIGR01506; ribC_arch; 1.
DR Pfam; PF00885; DMRL_synthase; 1.
DR SUPFAM; SSF52121; Lumazine synthase; 1.
PE 3: Inferred from homology;
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 152 AA; 16529 MW; AC280955C9381027 CRC64;
MSCIGVVDTT FARVDMGAVA IDELKSLLPH TAVRRLTVPG IKNTVWGALK LIKEGCDAVI
VLGWVGPTPV DKYSYLATSI GLMHLQIETG VLVLDVTVHE EEGGGDDKKL KEIALDRTRK
HVWNLVQMLR GGLEQYAGKG VRQGYPHAGE II
//
