ID G7X6H0_ASPKW Unreviewed; 1160 AA.
AC G7X6H0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ras guanine-nucleotide exchange protein {ECO:0000313|EMBL:GAA82582.1};
GN ORFNames=AKAW_00697 {ECO:0000313|EMBL:GAA82582.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA82582.1};
RN [1] {ECO:0000313|EMBL:GAA82582.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA82582.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
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DR EMBL; DF126448; GAA82582.1; -; Genomic_DNA.
DR AlphaFoldDB; G7X6H0; -.
DR STRING; 1033177.G7X6H0; -.
DR VEuPathDB; FungiDB:AKAW_00697; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; G7X6H0; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 60..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 695..815
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 875..1118
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 268..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 129498 MW; B23F337FE084E7FA CRC64;
MESMKRHIAP LKIEKGNLNY NYDDQQHHYH YQHNLEMSPP LTPYENKDDS MEQSETPRAV
FHNYLRAFYP YHPSGNVSPS TVTLPLDQGD IVLVHSVHTN GWADGTLLDT GARGWLPTNY
CEAYDQQPMR PLLKALTDFW DIIRGGCGFP LNDAGNQDLV RGLIAGVRYL LQKSECLTRD
CILVTSHDGL RRNRKALLAE LSSLVRTTKR FQEVASGNAT QDEMDYMVDE MLLKAFRIVT
RGVRFLDVWT EEVGLSRTIA ELEQQSGYQQ GPLTTVSETR PISEAAGSEA DTERNESRLM
NRSRLDMSRA STRLDDSQQT RPVSVTTKRI SVSHRVSTSG PAAIARNPNL ASERLNDAYD
AFLGVLGSFI GLHLQSRSST ELVVTTEQAV RSCRALLTVV EATCEHDPQG SGLLEQARDT
MYERLSELVY AARDAFRPAH SPDDELVFLP DEGKRLVDAA TDCVRAAGSC LAKARLMLEQ
CGDFELEAMP QDLPAATGAM TDANKTPQPP KTSTFAGHQN RSQEASLRLP PPPLQIPNSI
NNRYSPPTPG LTDDTTPSSF QSRNGASTPG TDMSSFPSTS HLSTSLDKLS FSSHDTQPIE
IPPHRDSQAK SDVSESFGRG ITSNGSSFTF NSRLRDSEMS GVSQTSTRAT SPDIGNHYQV
PSLKGSISHS TLAEETEEGE ANILEKTYAH ELIFKDGQIM GGSLRALVEK LTAHQSTPDA
MFVSTFYLTF RLFATPIEFA ETLVDRFNYI GDTPHTAGPV RLRVYNVFKG WLESHWRHDC
DNCALEYIVN FASTTLMHNL PSAGKRLVEL AEKVSMVHGP VVPRLVSSMG KTNTATAQYV
HPDTPLPPPI LGKKEVNLLK QWKNGEGTIT ILDFDPMELA RQFTIKESRI FCAILPEELL
ATEWMKKSGS LAVNVRAMAT LSTDLTHLVA DSILQLEEPK KRAAIIKHWV KIANKCLELS
NYDSLMAIIC SLNSSMISRL KRTWEVVSQK TKTTLEYLRG IVDVSRNYYV LRQRLQNRVP
PCLPFVGTYL TDLTFVDHGN QALRTLPTDE GDMAVINFDK HMKTAKIISE LQRFQIPYRL
TEVPELQAWM QNELVRVRSS GEKSLQTFYR RSLVLEPREV PQARMQPESS SSSILENAKD
KFDFLSWTHP SKSKSVATNG
//
