ID G7XPB9_ASPKW Unreviewed; 752 AA.
AC G7XPB9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Patatin-like phospholipase domain-containing protein {ECO:0000256|RuleBase:RU362055};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU362055};
GN ORFNames=AKAW_06779 {ECO:0000313|EMBL:GAA88665.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA88665.1};
RN [1] {ECO:0000313|EMBL:GAA88665.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA88665.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- FUNCTION: Lipid hydrolase. {ECO:0000256|RuleBase:RU362055}.
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362055}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362055}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000256|ARBA:ARBA00006104,
CC ECO:0000256|RuleBase:RU362055}.
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DR EMBL; DF126464; GAA88665.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XPB9; -.
DR STRING; 1033177.G7XPB9; -.
DR VEuPathDB; FungiDB:AKAW_06779; -.
DR eggNOG; KOG2214; Eukaryota.
DR InParanoid; G7XPB9; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR CDD; cd07232; Pat_PLPL; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF66; TRIACYLGLYCEROL LIPASE PTL2; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362055};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|RuleBase:RU362055};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU362055}; Membrane {ECO:0000256|RuleBase:RU362055};
KW Transmembrane {ECO:0000256|RuleBase:RU362055};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362055}.
FT TRANSMEM 89..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362055"
FT DOMAIN 277..468
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..197
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 628..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 85578 MW; D0F1465D42BEFEBF CRC64;
MNGAEKSAAG DTYDPSTIPD YDREFINPDD LRQFELALTD QGASPLVALN DWRPIYQRVR
RERGRRKEPR RTKDETREGV LYTVLKWPFL FTVFGWITAL AFAYTLTRVY IFLYEQWVTW
RGRRQSLRRQ LRAQTNYPDW QKAARALDDH LGNQRWKEID EYAYYDHLTI SNLVKQLKKV
RREVERERRE KRRGSGQSPA AEELCTLLEA CVKNNFAGVE NPRLYSEAYS GTKDLVQEYI
DELHACIQLV ADSKGIGSEE KLQHFKHLDT NFGRTALCLS GGATFAYYHF GVVRALLDNG
VLPEIITGTS GGALVAALVA TRTDEELKQL LVPALAHRIR ACQEGFPTWV WRWWRTGARF
DTLEWARQCS WFCRGSTTFR EAYERTGRIL NVSCVPSDPH SPTILANYLT SPNCVIWSAV
LASAAVPGIL NPVVLMTKKR DGTLAPYSFG HKWKDGSLRT DIPIKALNLH FNVNFTIVSQ
VNPHINLFFF SSRGTVGRPV THRKGRGWRG GFLGSAIEQY IKLDMNKWLR VLRHLELLPR
PMGQDWSEIW LQKFSGTVTI WPKTVPSDFF HILSDPNPER LARMLRVGQQ SAFPKLQFIK
NRLKIEIAVV KSLQKFAHAG GRPISPAPSR WRQNNDPDNH YNPSPRTATD PLNERLDHNL
PGRRGDNVNI TFGEGGGSGE DAHLLDGSLS ENSSNESAGR PTSSASSSRL LRVPEHRRGS
TGSSIFEEMR RQSAVFFDDV DMYGDDEALR PG
//
