ID G7XW37_ASPKW Unreviewed; 380 AA.
AC G7XW37;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:GAA91146.1};
GN ORFNames=AKAW_09260 {ECO:0000313|EMBL:GAA91146.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA91146.1};
RN [1] {ECO:0000313|EMBL:GAA91146.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA91146.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; DF126478; GAA91146.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XW37; -.
DR STRING; 1033177.G7XW37; -.
DR VEuPathDB; FungiDB:AKAW_09260; -.
DR eggNOG; KOG0023; Eukaryota.
DR InParanoid; G7XW37; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF3; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01980)-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 32..160
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 209..336
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 380 AA; 41545 MW; 51A207BC1BACC1A6 CRC64;
MPPPEHFHGY LSHSPTTPLT YAPYTPKPFT PTDIEINITH CGICGTDLHT LRSGWGPNTT
TYPCIVGHEI IGIVTRIGSS IPTYPNTTPL RIGDRVGIGA QTHSCLQPSC EECVAGKENY
CPRITGTYNS RYWDNETGKR SDVIAYGGFA RKWRGPAAFA FRIPERLESE VAAPLLCAGT
TVFAPLRKYL GDGTDSGKGK TVAVVGIGGL GHLGIMFAKA LGCERVIGIS RSNGKREDAV
KGLGADEFIA TGEEKGWEKK WSRTVDLILC TVDGDDMPLG KYLRLLKAGG TFVLVGAPEK
PLPRMRAFEL IGKGVNVTGS NIGSREDIRC MLEVAAEKGV RPWVETRRME EVNETLRDME
AGRARFRYVL VNGEERESRL
//
