ID G7XYM0_ASPKW Unreviewed; 477 AA.
AC G7XYM0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:GAA92029.1};
GN ORFNames=AKAW_10143 {ECO:0000313|EMBL:GAA92029.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA92029.1};
RN [1] {ECO:0000313|EMBL:GAA92029.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA92029.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; DF126487; GAA92029.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XYM0; -.
DR STRING; 1033177.G7XYM0; -.
DR VEuPathDB; FungiDB:AKAW_10143; -.
DR eggNOG; KOG2450; Eukaryota.
DR InParanoid; G7XYM0; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07106; ALDH_AldA-AAD23400; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044086; LUC3-like.
DR PANTHER; PTHR11699:SF263; ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 26..470
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 477 AA; 52118 MW; ACF384556F558CB6 CRC64;
MGSLDKIDFT TFYNTINNEL TTTAATRHSL NPATRKPNPP VPVSTASDLN RAVDSARNAF
KTWSKLSPSE RRSKVVALGE AIDLHAEELT ALLVQEQGKP HGQAAIEVSM SGTWCKQIPQ
LELSDEVLQD TDDQRVIQRF TPMGVVAGIV PWNFPLLLAV GKIAPAVYTG NCIIIKPSPF
TPYCALKIGE LAAKIFPPGV VQVLSDDGNI GPLMTAHPGI NKISFTGSTE TGKRIMRHCA
DTLKSVTLEL GGNDPAIVCE DVDIEQVVPQ IATLSFLVSA QVCMMIKRLY VHEKIYDKFL
EAFVNFTKNL KVGNGTEPDV FFGPVQNEMQ YGKLKDLFSS IQTENLKPAL GGSITESEGY
FVTPTIIDNP PDNSRVVQEE PFGPILPLMK WSDEDEVIAR ANDTDTGLGA SVWSKDVDRA
QRIGTQLESG SVWINSHFQV APNIPFGGMK ASGNGREWGL EGLKSYTQSQ MLWVKKA
//
